Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of...

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Autores principales: Laura Pirovano, Simone Culurgioni, Manuel Carminati, Andrea Alfieri, Silvia Monzani, Valentina Cecatiello, Chiara Gaddoni, Francesca Rizzelli, James Foadi, Sebastiano Pasqualato, Marina Mapelli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/cca2029813694381ba0884810c0da218
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