Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation

Osteoarthritis (OA) is the most prevalent joint disease worldwide, making it a major cause of pain and disability. Identified as a chronic and progressive disease, effective treatment at the early stages of OA has become critical to its management. Jintiange (Jtg) capsules are a traditional Chinese...

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Autores principales:	Chenyang Zhuang, Zixiang Wang, Weisin Chen, Hanquan Wang, Bo Tian, Hong Lin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Jintiange capsule osteoarthritis subchondral bone cartilage osteoclast chondrocyte Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cca290cf01e4412f8179f3bba81f8255
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spelling	oai:doaj.org-article:cca290cf01e4412f8179f3bba81f82552021-11-11T06:16:58ZJintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation1663-981210.3389/fphar.2021.762543https://doaj.org/article/cca290cf01e4412f8179f3bba81f82552021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.762543/fullhttps://doaj.org/toc/1663-9812Osteoarthritis (OA) is the most prevalent joint disease worldwide, making it a major cause of pain and disability. Identified as a chronic and progressive disease, effective treatment at the early stages of OA has become critical to its management. Jintiange (Jtg) capsules are a traditional Chinese medicine produced from multiple organic components of various animal bones and routinely used to treat osteoporosis in China. However, the effect of Jtg on subchondral bone and cartilage degeneration in OA remains unknown. The purpose of the present study was to investigate the biomolecular role and underlying mechanisms of Jtg in OA progression. Herein, we found that Jtg inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation and it functions through the NF-κB signaling pathway. Jtg also inhibited chondrocyte apoptosis via reducing the reactive oxygen species concentration in these cells. Moreover, in vivo evaluation revealed that Jtg significantly attenuates subchondral bone remodeling and cartilage destruction in anterior cruciate ligament transection (ACLT) mouse models. Taken together, our data demonstrate that Jtg inhibits osteoclast differentiation in subchondral bone and chondrocyte apoptosis in cartilage, supporting its potential therapeutic value for treating OA.Chenyang ZhuangZixiang WangWeisin ChenHanquan WangBo TianHong LinHong LinFrontiers Media S.A.articleJintiange capsuleosteoarthritissubchondral bonecartilageosteoclastchondrocyteTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Jintiange capsule osteoarthritis subchondral bone cartilage osteoclast chondrocyte Therapeutics. Pharmacology RM1-950
spellingShingle	Jintiange capsule osteoarthritis subchondral bone cartilage osteoclast chondrocyte Therapeutics. Pharmacology RM1-950 Chenyang Zhuang Zixiang Wang Weisin Chen Hanquan Wang Bo Tian Hong Lin Hong Lin Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
description	Osteoarthritis (OA) is the most prevalent joint disease worldwide, making it a major cause of pain and disability. Identified as a chronic and progressive disease, effective treatment at the early stages of OA has become critical to its management. Jintiange (Jtg) capsules are a traditional Chinese medicine produced from multiple organic components of various animal bones and routinely used to treat osteoporosis in China. However, the effect of Jtg on subchondral bone and cartilage degeneration in OA remains unknown. The purpose of the present study was to investigate the biomolecular role and underlying mechanisms of Jtg in OA progression. Herein, we found that Jtg inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation and it functions through the NF-κB signaling pathway. Jtg also inhibited chondrocyte apoptosis via reducing the reactive oxygen species concentration in these cells. Moreover, in vivo evaluation revealed that Jtg significantly attenuates subchondral bone remodeling and cartilage destruction in anterior cruciate ligament transection (ACLT) mouse models. Taken together, our data demonstrate that Jtg inhibits osteoclast differentiation in subchondral bone and chondrocyte apoptosis in cartilage, supporting its potential therapeutic value for treating OA.
format	article
author	Chenyang Zhuang Zixiang Wang Weisin Chen Hanquan Wang Bo Tian Hong Lin Hong Lin
author_facet	Chenyang Zhuang Zixiang Wang Weisin Chen Hanquan Wang Bo Tian Hong Lin Hong Lin
author_sort	Chenyang Zhuang
title	Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
title_short	Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
title_full	Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
title_fullStr	Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
title_full_unstemmed	Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
title_sort	jintiange capsules ameliorate osteoarthritis by modulating subchondral bone remodeling and protecting cartilage against degradation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cca290cf01e4412f8179f3bba81f8255
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Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation

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