Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers

Abstract The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in female broilers. To this end, first a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eirini Tarsani, Andreas Kranis, Gerasimos Maniatis, Ariadne L. Hager-Theodorides, Antonios Kominakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cca4d7fa680f4962b293603d5392973b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cca4d7fa680f4962b293603d5392973b
record_format	dspace
spelling	oai:doaj.org-article:cca4d7fa680f4962b293603d5392973b2021-12-02T18:17:42ZDetection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers10.1038/s41598-021-86817-82045-2322https://doaj.org/article/cca4d7fa680f4962b293603d5392973b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86817-8https://doaj.org/toc/2045-2322Abstract The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in female broilers. To this end, first a bivariate genome-wide association and second stepwise conditional-joint analyses were performed using 2586 female broilers and 240 k autosomal SNPs. The aforementioned analyses resulted in a total number of 49 independent cross-phenotype (CP) significant SNPs with 35 independent markers showing antagonistic action i.e., positive effects on one trait and negative effects on the other trait. A number of 33 independent CP SNPs were located within 26 and 14 protein coding and long non-coding RNA genes, respectively. Furthermore, 26 independent markers were situated within 44 reported QTLs, most of them related to growth traits. Investigation of the functional role of protein coding genes via pathway and gene ontology analyses highlighted four candidates (CPEB3, ACVR1, MAST2 and CACNA1H) as most plausible pleiotropic genes for the traits under study. Three candidates (CPEB3, MAST2 and CACNA1H) were associated with antagonistic pleiotropy, while ACVR1 with synergistic pleiotropic action. Current results provide a novel insight into the biological mechanism of the genetic trade-off between growth and reproduction, in broilers.Eirini TarsaniAndreas KranisGerasimos ManiatisAriadne L. Hager-TheodoridesAntonios KominakisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eirini Tarsani Andreas Kranis Gerasimos Maniatis Ariadne L. Hager-Theodorides Antonios Kominakis Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
description	Abstract The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in female broilers. To this end, first a bivariate genome-wide association and second stepwise conditional-joint analyses were performed using 2586 female broilers and 240 k autosomal SNPs. The aforementioned analyses resulted in a total number of 49 independent cross-phenotype (CP) significant SNPs with 35 independent markers showing antagonistic action i.e., positive effects on one trait and negative effects on the other trait. A number of 33 independent CP SNPs were located within 26 and 14 protein coding and long non-coding RNA genes, respectively. Furthermore, 26 independent markers were situated within 44 reported QTLs, most of them related to growth traits. Investigation of the functional role of protein coding genes via pathway and gene ontology analyses highlighted four candidates (CPEB3, ACVR1, MAST2 and CACNA1H) as most plausible pleiotropic genes for the traits under study. Three candidates (CPEB3, MAST2 and CACNA1H) were associated with antagonistic pleiotropy, while ACVR1 with synergistic pleiotropic action. Current results provide a novel insight into the biological mechanism of the genetic trade-off between growth and reproduction, in broilers.
format	article
author	Eirini Tarsani Andreas Kranis Gerasimos Maniatis Ariadne L. Hager-Theodorides Antonios Kominakis
author_facet	Eirini Tarsani Andreas Kranis Gerasimos Maniatis Ariadne L. Hager-Theodorides Antonios Kominakis
author_sort	Eirini Tarsani
title	Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_short	Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_full	Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_fullStr	Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_full_unstemmed	Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
title_sort	detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cca4d7fa680f4962b293603d5392973b
work_keys_str_mv	AT eirinitarsani detectionoflociexhibitingpleiotropiceffectsonbodyweightandeggnumberinfemalebroilers AT andreaskranis detectionoflociexhibitingpleiotropiceffectsonbodyweightandeggnumberinfemalebroilers AT gerasimosmaniatis detectionoflociexhibitingpleiotropiceffectsonbodyweightandeggnumberinfemalebroilers AT ariadnelhagertheodorides detectionoflociexhibitingpleiotropiceffectsonbodyweightandeggnumberinfemalebroilers AT antonioskominakis detectionoflociexhibitingpleiotropiceffectsonbodyweightandeggnumberinfemalebroilers
_version_	1718378299386757120

Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers

Ejemplares similares