Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, lead...

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Autores principales:	Wei Deng, Yan Xu, Wenchun Chen, David S. Paul, Anum K. Syed, Matthew A. Dragovich, Xin Liang, Philip Zakas, Michael C. Berndt, Jorge Di Paola, Jerry Ware, Francois Lanza, Christopher B. Doering, Wolfgang Bergmeier, X. Frank Zhang, Renhao Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cca6cab2d9084967958579b065cd46c9
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spelling	oai:doaj.org-article:cca6cab2d9084967958579b065cd46c92021-12-02T14:39:54ZPlatelet clearance via shear-induced unfolding of a membrane mechanoreceptor10.1038/ncomms128632041-1723https://doaj.org/article/cca6cab2d9084967958579b065cd46c92016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12863https://doaj.org/toc/2041-1723The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance.Wei DengYan XuWenchun ChenDavid S. PaulAnum K. SyedMatthew A. DragovichXin LiangPhilip ZakasMichael C. BerndtJorge Di PaolaJerry WareFrancois LanzaChristopher B. DoeringWolfgang BergmeierX. Frank ZhangRenhao LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Deng Yan Xu Wenchun Chen David S. Paul Anum K. Syed Matthew A. Dragovich Xin Liang Philip Zakas Michael C. Berndt Jorge Di Paola Jerry Ware Francois Lanza Christopher B. Doering Wolfgang Bergmeier X. Frank Zhang Renhao Li Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
description	The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance.
format	article
author	Wei Deng Yan Xu Wenchun Chen David S. Paul Anum K. Syed Matthew A. Dragovich Xin Liang Philip Zakas Michael C. Berndt Jorge Di Paola Jerry Ware Francois Lanza Christopher B. Doering Wolfgang Bergmeier X. Frank Zhang Renhao Li
author_facet	Wei Deng Yan Xu Wenchun Chen David S. Paul Anum K. Syed Matthew A. Dragovich Xin Liang Philip Zakas Michael C. Berndt Jorge Di Paola Jerry Ware Francois Lanza Christopher B. Doering Wolfgang Bergmeier X. Frank Zhang Renhao Li
author_sort	Wei Deng
title	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_short	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_full	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_fullStr	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_full_unstemmed	Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
title_sort	platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cca6cab2d9084967958579b065cd46c9
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Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

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