High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy

Zi-Wei Yu,* Rong Liu,* Xin Li, Ying Wang, Yu-Hong Fu, Hui-Yao Li, Yue Yuan, Xin-Yuan Gao Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-Yuan G...

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Autores principales:	Yu ZW, Liu R, Li X, Wang Y, Fu YH, Li HY, Yuan Y, Gao XY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	neuron-specific enolase mild cognitive impairment type 2 diabetes mellitus diabetic retinopathy Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/cca7200516a04d918048ef4954df4558
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spelling	oai:doaj.org-article:cca7200516a04d918048ef4954df45582021-12-02T12:33:26ZHigh Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy1178-7007https://doaj.org/article/cca7200516a04d918048ef4954df45582020-04-01T00:00:00Zhttps://www.dovepress.com/high-serum-neuron-specific-enolase-level-is-associated-with-mild-cogni-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Zi-Wei Yu,* Rong Liu,* Xin Li, Ying Wang, Yu-Hong Fu, Hui-Yao Li, Yue Yuan, Xin-Yuan Gao Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-Yuan Gao Tel +86 13904517001 Email 15369337970@163.comPurpose: Diabetic retinopathy (DR) can increase the risk of mild cognitive impairment (MCI), which has been confirmed by previous researches. With the frequent occurrence of MCI in patients with DR, the early detection of MCI has become a research hot-spot. The aim of this study was to investigate the relationship between neuron-specific enolase (NSE) and MCI in patients with DR.Patients and Methods: A total of 124 patients with DR, including 56 MCI patients and 68 normal cognition patients, were recruited in this cross-sectional study. The demographic and clinical data of patients were collected through questionnaires. Serum NSE was measured using electrochemiluminescence immunoassay. The Minimum Mental State Examination (MMSE) scale was used to evaluate the cognitive function of the participants.Results: Compared with the normal cognition group, serum NSE levels and HbA1c levels in the MCI group were higher, while MMSE scores and educational level were lower (P< 0.05). Serum NSE levels were significantly negatively correlated with MMSE total score, attention and calculation score, and language score (P< 0.05). After adjusting for confounding factors, serum NSE still increased the MCI risk in DR patients (OR:1.606, 95CI%:1.264– 2.041, P< 0.001). The areas under the receiver operating characteristics (ROC) curves (AUC) of the crude model and the adjusted model were 0.75 and 0.73, respectively.Conclusion: A high serum NSE level is an independent risk factor for MCI in DR patients. In addition, serum NSE is expected to be a potential biomarker in DR patients with MCI.Keywords: neuron-specific enolase, mild cognitive impairment, type 2 diabetes mellitus, diabetic retinopathyYu ZWLiu RLi XWang YFu YHLi HYYuan YGao XYDove Medical Pressarticleneuron-specific enolasemild cognitive impairmenttype 2 diabetes mellitusdiabetic retinopathySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1359-1365 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuron-specific enolase mild cognitive impairment type 2 diabetes mellitus diabetic retinopathy Specialties of internal medicine RC581-951
spellingShingle	neuron-specific enolase mild cognitive impairment type 2 diabetes mellitus diabetic retinopathy Specialties of internal medicine RC581-951 Yu ZW Liu R Li X Wang Y Fu YH Li HY Yuan Y Gao XY High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy
description	Zi-Wei Yu,* Rong Liu,* Xin Li, Ying Wang, Yu-Hong Fu, Hui-Yao Li, Yue Yuan, Xin-Yuan Gao Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin-Yuan Gao Tel +86 13904517001 Email 15369337970@163.comPurpose: Diabetic retinopathy (DR) can increase the risk of mild cognitive impairment (MCI), which has been confirmed by previous researches. With the frequent occurrence of MCI in patients with DR, the early detection of MCI has become a research hot-spot. The aim of this study was to investigate the relationship between neuron-specific enolase (NSE) and MCI in patients with DR.Patients and Methods: A total of 124 patients with DR, including 56 MCI patients and 68 normal cognition patients, were recruited in this cross-sectional study. The demographic and clinical data of patients were collected through questionnaires. Serum NSE was measured using electrochemiluminescence immunoassay. The Minimum Mental State Examination (MMSE) scale was used to evaluate the cognitive function of the participants.Results: Compared with the normal cognition group, serum NSE levels and HbA1c levels in the MCI group were higher, while MMSE scores and educational level were lower (P< 0.05). Serum NSE levels were significantly negatively correlated with MMSE total score, attention and calculation score, and language score (P< 0.05). After adjusting for confounding factors, serum NSE still increased the MCI risk in DR patients (OR:1.606, 95CI%:1.264– 2.041, P< 0.001). The areas under the receiver operating characteristics (ROC) curves (AUC) of the crude model and the adjusted model were 0.75 and 0.73, respectively.Conclusion: A high serum NSE level is an independent risk factor for MCI in DR patients. In addition, serum NSE is expected to be a potential biomarker in DR patients with MCI.Keywords: neuron-specific enolase, mild cognitive impairment, type 2 diabetes mellitus, diabetic retinopathy
format	article
author	Yu ZW Liu R Li X Wang Y Fu YH Li HY Yuan Y Gao XY
author_facet	Yu ZW Liu R Li X Wang Y Fu YH Li HY Yuan Y Gao XY
author_sort	Yu ZW
title	High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy
title_short	High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy
title_full	High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy
title_fullStr	High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy
title_full_unstemmed	High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy
title_sort	high serum neuron-specific enolase level is associated with mild cognitive impairment in patients with diabetic retinopathy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/cca7200516a04d918048ef4954df4558
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High Serum Neuron-Specific Enolase Level Is Associated with Mild Cognitive Impairment in Patients with Diabetic Retinopathy

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