The effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological study

Background Data: Phosphatidylcholine/deoxycholate is now widely used in injection lipolysis mainly for aesthetic purposes inducing lipolysis in subcutaneous fat for body contouring and also for shrinking small subcutaneous lipomas. In this work, the authors discuss the effects of phosphatidylcholine...

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Autores principales:	Hanan El-gowelli, Bassma Elsabba MD, Hisham Elsaghir, Emad Yosry
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Spine Association 2013
Materias:	phosphatidyl choline spinal lipoma nerve tissue Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ccaa86b934d245119fac791c2c313823
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spelling	oai:doaj.org-article:ccaa86b934d245119fac791c2c3138232021-12-02T04:13:49ZThe effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological studyDOI:10.21608/ESJ.2013.38472314-89502314-8969https://doaj.org/article/ccaa86b934d245119fac791c2c3138232013-10-01T00:00:00Zhttp://www.esj.journals.ekb.eg/article_3847.htmlhttps://doaj.org/toc/2314-8950https://doaj.org/toc/2314-8969Background Data: Phosphatidylcholine/deoxycholate is now widely used in injection lipolysis mainly for aesthetic purposes inducing lipolysis in subcutaneous fat for body contouring and also for shrinking small subcutaneous lipomas. In this work, the authors discuss the effects of phosphatidylcholine dissolved in deoxycholate on nervous tissues in rats to assess the hazards of injection lipolysis in treatment of spinal lipomas as an alternative to surgery. Purpose: to highlight the histopathological effects of phosphatidylcholine on neurological tissues of a rat model to determine whether it is safe to use it as a mesotherapeutic agent for treating spinal lipomas as an alternative for surgery. Study design: a prospective histopathological study on rat model. Material and Methods: 12 young female Wistar rats (2 month old) were divided equally into 2 groups. The treatment group was injected percutaneously by Lipostabil® (0.1 ml/rat/day containing 50 mg/ml phosphatidylcholine dissolved in deoxycholate) in the groin area infiltrating the femoral bundle and the control group was injected with 0.1 ml/rat/day normal saline. The injection was repeated for 4 successive days. Biopsies were harvested on the fourth day from the femoral bundle and studied by light microscopy. The pathology was scored semi-quantitatively for inflammation, necrosis, fibrosis, and nerve damage.Results: Repeated injection of phosphatidyl choline deoxycholate caused intense inflammation adjacent to the nerve leading to neural damage, deposition of collagen fibers amongst the inflammatory background as an early sign of fibrogenesis and tissue necrosis Conclusion: The current data highlights the risk of using such combinations near nerves not only spinal lipomas for its intense inflammatory and necrotic effects. (2013ESJ056)Hanan El-gowelli Bassma Elsabba MDHisham ElsaghirEmad YosryEgyptian Spine Associationarticlephosphatidyl cholinespinal lipomanerve tissueNeurology. Diseases of the nervous systemRC346-429ENEgyptian Spine Journal, Vol 8, Iss 1, Pp 42-48 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	phosphatidyl choline spinal lipoma nerve tissue Neurology. Diseases of the nervous system RC346-429
spellingShingle	phosphatidyl choline spinal lipoma nerve tissue Neurology. Diseases of the nervous system RC346-429 Hanan El-gowelli Bassma Elsabba MD Hisham Elsaghir Emad Yosry The effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological study
description	Background Data: Phosphatidylcholine/deoxycholate is now widely used in injection lipolysis mainly for aesthetic purposes inducing lipolysis in subcutaneous fat for body contouring and also for shrinking small subcutaneous lipomas. In this work, the authors discuss the effects of phosphatidylcholine dissolved in deoxycholate on nervous tissues in rats to assess the hazards of injection lipolysis in treatment of spinal lipomas as an alternative to surgery. Purpose: to highlight the histopathological effects of phosphatidylcholine on neurological tissues of a rat model to determine whether it is safe to use it as a mesotherapeutic agent for treating spinal lipomas as an alternative for surgery. Study design: a prospective histopathological study on rat model. Material and Methods: 12 young female Wistar rats (2 month old) were divided equally into 2 groups. The treatment group was injected percutaneously by Lipostabil® (0.1 ml/rat/day containing 50 mg/ml phosphatidylcholine dissolved in deoxycholate) in the groin area infiltrating the femoral bundle and the control group was injected with 0.1 ml/rat/day normal saline. The injection was repeated for 4 successive days. Biopsies were harvested on the fourth day from the femoral bundle and studied by light microscopy. The pathology was scored semi-quantitatively for inflammation, necrosis, fibrosis, and nerve damage.Results: Repeated injection of phosphatidyl choline deoxycholate caused intense inflammation adjacent to the nerve leading to neural damage, deposition of collagen fibers amongst the inflammatory background as an early sign of fibrogenesis and tissue necrosis Conclusion: The current data highlights the risk of using such combinations near nerves not only spinal lipomas for its intense inflammatory and necrotic effects. (2013ESJ056)
format	article
author	Hanan El-gowelli Bassma Elsabba MD Hisham Elsaghir Emad Yosry
author_facet	Hanan El-gowelli Bassma Elsabba MD Hisham Elsaghir Emad Yosry
author_sort	Hanan El-gowelli
title	The effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological study
title_short	The effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological study
title_full	The effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological study
title_fullStr	The effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological study
title_full_unstemmed	The effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological study
title_sort	effect of phosphatidylcholine/ deoxycholate on nervous tissues: a histopathological study
publisher	Egyptian Spine Association
publishDate	2013
url	https://doaj.org/article/ccaa86b934d245119fac791c2c313823
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The effect of phosphatidylcholine/ deoxycholate on nervous tissues: A histopathological study

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