"Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.

Leishmaniases remain a major public health problem today (350 million people at risk, 12 million infected, and 2 million new infections per year). Despite the considerable progress in cellular and molecular biology and in evolutionary genetics since 1990, the debate on the population structure and r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Virginie Rougeron, Thierry De Meeûs, Sandrine Kako Ouraga, Mallorie Hide, Anne-Laure Bañuls
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ccaac637d3184accb49d565e5bd9bccd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ccaac637d3184accb49d565e5bd9bccd
record_format	dspace
spelling	oai:doaj.org-article:ccaac637d3184accb49d565e5bd9bccd2021-11-18T06:01:42Z"Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.1553-73661553-737410.1371/journal.ppat.1001004https://doaj.org/article/ccaac637d3184accb49d565e5bd9bccd2010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808896/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Leishmaniases remain a major public health problem today (350 million people at risk, 12 million infected, and 2 million new infections per year). Despite the considerable progress in cellular and molecular biology and in evolutionary genetics since 1990, the debate on the population structure and reproductive mode of Leishmania is far from being settled and therefore deserves further investigation. Two major hypotheses coexist: clonality versus sexuality. However, because of the lack of clear evidence (experimental or biological confirmation) of sexuality in Leishmania parasites, until today it has been suggested and even accepted that Leishmania species were mainly clonal with infrequent genetic recombination (see [1] for review). Two recent publications, one on Leishmania major (an in vitro experimental study) and one on Leishmania braziliensis (a population genetics analysis), once again have challenged the hypothesis of clonal reproduction. Indeed, the first study experimentally evidenced genetic recombination and proposed that Leishmania parasites are capable of having a sexual cycle consistent with meiotic processes inside the insect vector. The second investigation, based on population genetics studies, showed strong homozygosities, an observation that is incompatible with a predominantly clonal mode of reproduction at an ecological time scale (approximately 20-500 generations). These studies highlight the need to advance the knowledge of Leishmania biology. In this paper, we first review the reasons stimulating the continued debate and then detail the next essential steps to be taken to clarify the Leishmania reproduction model. Finally, we widen the discussion to other Trypanosomatidae and show that the progress in Leishmania biology can improve our knowledge of the evolutionary genetics of American and African trypanosomes.Virginie RougeronThierry De MeeûsSandrine Kako OuragaMallorie HideAnne-Laure BañulsPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 8, p e1001004 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Virginie Rougeron Thierry De Meeûs Sandrine Kako Ouraga Mallorie Hide Anne-Laure Bañuls "Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.
description	Leishmaniases remain a major public health problem today (350 million people at risk, 12 million infected, and 2 million new infections per year). Despite the considerable progress in cellular and molecular biology and in evolutionary genetics since 1990, the debate on the population structure and reproductive mode of Leishmania is far from being settled and therefore deserves further investigation. Two major hypotheses coexist: clonality versus sexuality. However, because of the lack of clear evidence (experimental or biological confirmation) of sexuality in Leishmania parasites, until today it has been suggested and even accepted that Leishmania species were mainly clonal with infrequent genetic recombination (see [1] for review). Two recent publications, one on Leishmania major (an in vitro experimental study) and one on Leishmania braziliensis (a population genetics analysis), once again have challenged the hypothesis of clonal reproduction. Indeed, the first study experimentally evidenced genetic recombination and proposed that Leishmania parasites are capable of having a sexual cycle consistent with meiotic processes inside the insect vector. The second investigation, based on population genetics studies, showed strong homozygosities, an observation that is incompatible with a predominantly clonal mode of reproduction at an ecological time scale (approximately 20-500 generations). These studies highlight the need to advance the knowledge of Leishmania biology. In this paper, we first review the reasons stimulating the continued debate and then detail the next essential steps to be taken to clarify the Leishmania reproduction model. Finally, we widen the discussion to other Trypanosomatidae and show that the progress in Leishmania biology can improve our knowledge of the evolutionary genetics of American and African trypanosomes.
format	article
author	Virginie Rougeron Thierry De Meeûs Sandrine Kako Ouraga Mallorie Hide Anne-Laure Bañuls
author_facet	Virginie Rougeron Thierry De Meeûs Sandrine Kako Ouraga Mallorie Hide Anne-Laure Bañuls
author_sort	Virginie Rougeron
title	"Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.
title_short	"Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.
title_full	"Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.
title_fullStr	"Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.
title_full_unstemmed	"Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.
title_sort	"everything you always wanted to know about sex (but were afraid to ask)" in leishmania after two decades of laboratory and field analyses.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/ccaac637d3184accb49d565e5bd9bccd
work_keys_str_mv	AT virginierougeron everythingyoualwayswantedtoknowaboutsexbutwereafraidtoaskinleishmaniaaftertwodecadesoflaboratoryandfieldanalyses AT thierrydemeeus everythingyoualwayswantedtoknowaboutsexbutwereafraidtoaskinleishmaniaaftertwodecadesoflaboratoryandfieldanalyses AT sandrinekakoouraga everythingyoualwayswantedtoknowaboutsexbutwereafraidtoaskinleishmaniaaftertwodecadesoflaboratoryandfieldanalyses AT malloriehide everythingyoualwayswantedtoknowaboutsexbutwereafraidtoaskinleishmaniaaftertwodecadesoflaboratoryandfieldanalyses AT annelaurebanuls everythingyoualwayswantedtoknowaboutsexbutwereafraidtoaskinleishmaniaaftertwodecadesoflaboratoryandfieldanalyses
_version_	1718424695017046016

"Everything you always wanted to know about sex (but were afraid to ask)" in Leishmania after two decades of laboratory and field analyses.

Ejemplares similares