Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones

Chiral spirocyclic compounds are important structural motifs for drug discovery. Here, the authors report a synthetic route to spirocycles based on enantioselective cycloaddition of activated spirocyclopropyl oxindoles, which act as donor-acceptor cyclopropanes.

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Autores principales:	Peng-Wei Xu, Jia-Kuan Liu, Lan Shen, Zhong-Yan Cao, Xiao-Li Zhao, Jun Yan, Jian Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccad5ca9a7d34c97a43a0298b9280a02
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spelling	oai:doaj.org-article:ccad5ca9a7d34c97a43a0298b9280a022021-12-02T14:42:51ZDiastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones10.1038/s41467-017-01451-12041-1723https://doaj.org/article/ccad5ca9a7d34c97a43a0298b9280a022017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01451-1https://doaj.org/toc/2041-1723Chiral spirocyclic compounds are important structural motifs for drug discovery. Here, the authors report a synthetic route to spirocycles based on enantioselective cycloaddition of activated spirocyclopropyl oxindoles, which act as donor-acceptor cyclopropanes.Peng-Wei XuJia-Kuan LiuLan ShenZhong-Yan CaoXiao-Li ZhaoJun YanJian ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng-Wei Xu Jia-Kuan Liu Lan Shen Zhong-Yan Cao Xiao-Li Zhao Jun Yan Jian Zhou Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones
description	Chiral spirocyclic compounds are important structural motifs for drug discovery. Here, the authors report a synthetic route to spirocycles based on enantioselective cycloaddition of activated spirocyclopropyl oxindoles, which act as donor-acceptor cyclopropanes.
format	article
author	Peng-Wei Xu Jia-Kuan Liu Lan Shen Zhong-Yan Cao Xiao-Li Zhao Jun Yan Jian Zhou
author_facet	Peng-Wei Xu Jia-Kuan Liu Lan Shen Zhong-Yan Cao Xiao-Li Zhao Jun Yan Jian Zhou
author_sort	Peng-Wei Xu
title	Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones
title_short	Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones
title_full	Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones
title_fullStr	Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones
title_full_unstemmed	Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones
title_sort	diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ccad5ca9a7d34c97a43a0298b9280a02
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Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones

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