DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus

Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-r...

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Autores principales:	Pedram Shafiei-Jahani, Benjamin P. Hurrell, Lauriane Galle-Treger, Doumet Georges Helou, Emily Howard, Jacob Painter, Richard Lo, Gavin Lewis, Pejman Soroosh, Omid Akbari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccb0b1c8242f4157b1256882b0fb6cb3
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spelling	oai:doaj.org-article:ccb0b1c8242f4157b1256882b0fb6cb32021-12-02T18:33:52ZDR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus10.1038/s41467-020-18601-72041-1723https://doaj.org/article/ccb0b1c8242f4157b1256882b0fb6cb32020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18601-7https://doaj.org/toc/2041-1723Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-resistance.Pedram Shafiei-JahaniBenjamin P. HurrellLauriane Galle-TregerDoumet Georges HelouEmily HowardJacob PainterRichard LoGavin LewisPejman SorooshOmid AkbariNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pedram Shafiei-Jahani Benjamin P. Hurrell Lauriane Galle-Treger Doumet Georges Helou Emily Howard Jacob Painter Richard Lo Gavin Lewis Pejman Soroosh Omid Akbari DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
description	Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-resistance.
format	article
author	Pedram Shafiei-Jahani Benjamin P. Hurrell Lauriane Galle-Treger Doumet Georges Helou Emily Howard Jacob Painter Richard Lo Gavin Lewis Pejman Soroosh Omid Akbari
author_facet	Pedram Shafiei-Jahani Benjamin P. Hurrell Lauriane Galle-Treger Doumet Georges Helou Emily Howard Jacob Painter Richard Lo Gavin Lewis Pejman Soroosh Omid Akbari
author_sort	Pedram Shafiei-Jahani
title	DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
title_short	DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
title_full	DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
title_fullStr	DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
title_full_unstemmed	DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
title_sort	dr3 stimulation of adipose resident ilc2s ameliorates type 2 diabetes mellitus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ccb0b1c8242f4157b1256882b0fb6cb3
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DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus

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