Promoter hypermethylation of ARID1A gene is responsible for its low mRNA expression in many invasive breast cancers.

Promoter hypermethylation of ARID1A gene is responsible for its low mRNA expression in many invasive breast cancers.

ARID1A (AT-rich interactive domain 1A) has recently been identified as a tumor suppressor gene. Its mRNA expression is significantly low in many breast cancers; this is often associated with more aggressive phenotypes. However, the underlying molecular mechanism for its low expression has not been f...

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Main Authors: Xianyu Zhang, Qian Sun, Ming Shan, Ming Niu, Tong Liu, Bingshu Xia, Xiaoshuan Liang, Wei Wei, Shanshan Sun, Youxue Zhang, Xiaolong Sean Liu, Qingbin Song, Yanmei Yang, Yuyan Ma, Yang Liu, Long Yang, Yanlv Ren, Guoqiang Zhang, Da Pang
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/ccb189c963c444978ae2596d21b21d86
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