C-reactive protein concentration predicts change in body mass index during childhood.

<h4>Objective</h4>Inflammation may constitute an underlying mechanism for increased risk of developing chronic diseases in later years, but few prospective studies have assessed the influence of low-grade inflammation on body weight gain, particularly among children in low- to middle-inc...

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Autores principales:	Barbara H Lourenço, Marly A Cardoso, ACTION Study Team
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ccb224fa2a1f4b88b308d640967ccfa5
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spelling	oai:doaj.org-article:ccb224fa2a1f4b88b308d640967ccfa52021-11-18T08:29:26ZC-reactive protein concentration predicts change in body mass index during childhood.1932-620310.1371/journal.pone.0090357https://doaj.org/article/ccb224fa2a1f4b88b308d640967ccfa52014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24603645/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Inflammation may constitute an underlying mechanism for increased risk of developing chronic diseases in later years, but few prospective studies have assessed the influence of low-grade inflammation on body weight gain, particularly among children in low- to middle-income settings with lower prevalence of overweight and obesity. We aimed to investigate whether C-reactive protein (CRP), as a biomarker of low-grade inflammation, predicts changes in body mass index-for-age z scores (BAZ) during childhood.<h4>Methods</h4>A population-based longitudinal study was conducted in the Brazilian Amazon among children aged ≤10 years in 2007, with follow-up visits in 2009 and 2012. Outcome was annual change in BAZ. As the main exposure of interest, CRP concentrations were divided into four categories, with values <1 mg/L divided in tertiles plus a fourth category with values ranging from 1 to 10 mg/L. Children were simultaneously screened for iron and vitamin A deficiencies, diarrhea, and wheezing. We used mixed-effect linear regression models to measure the effect of CRP concentrations on annual BAZ change and linear regression models to explore CRP predictors at baseline.<h4>Results</h4>At baseline, 1007 children had CRP and anthropometric data [mean (SD) age: 5.3 (2.9) years; 50.9% male, 84.5% mulatto/mixed-race, 14.0% at risk for overweight or obesity, 4.8% stunted]; 737 were successfully followed up. Morbidities and nutritional deficiencies were widespread. Among participants aged >5 years, children in the highest tertile of CRP <1 mg/L at baseline, regarded as an indicator of low-grade inflammation, had a 0.04 z/y higher gain in BAZ (95% CI: 0.01, 0.09 z/y) during follow-up. CRP was positively associated with household poverty and worse nutritional indicators.<h4>Conclusions</h4>We found evidence of a role for low-grade inflammation in predicting annual BAZ gain among children aged >5 years.Barbara H LourençoMarly A CardosoACTION Study TeamPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90357 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barbara H Lourenço Marly A Cardoso ACTION Study Team C-reactive protein concentration predicts change in body mass index during childhood.
description	<h4>Objective</h4>Inflammation may constitute an underlying mechanism for increased risk of developing chronic diseases in later years, but few prospective studies have assessed the influence of low-grade inflammation on body weight gain, particularly among children in low- to middle-income settings with lower prevalence of overweight and obesity. We aimed to investigate whether C-reactive protein (CRP), as a biomarker of low-grade inflammation, predicts changes in body mass index-for-age z scores (BAZ) during childhood.<h4>Methods</h4>A population-based longitudinal study was conducted in the Brazilian Amazon among children aged ≤10 years in 2007, with follow-up visits in 2009 and 2012. Outcome was annual change in BAZ. As the main exposure of interest, CRP concentrations were divided into four categories, with values <1 mg/L divided in tertiles plus a fourth category with values ranging from 1 to 10 mg/L. Children were simultaneously screened for iron and vitamin A deficiencies, diarrhea, and wheezing. We used mixed-effect linear regression models to measure the effect of CRP concentrations on annual BAZ change and linear regression models to explore CRP predictors at baseline.<h4>Results</h4>At baseline, 1007 children had CRP and anthropometric data [mean (SD) age: 5.3 (2.9) years; 50.9% male, 84.5% mulatto/mixed-race, 14.0% at risk for overweight or obesity, 4.8% stunted]; 737 were successfully followed up. Morbidities and nutritional deficiencies were widespread. Among participants aged >5 years, children in the highest tertile of CRP <1 mg/L at baseline, regarded as an indicator of low-grade inflammation, had a 0.04 z/y higher gain in BAZ (95% CI: 0.01, 0.09 z/y) during follow-up. CRP was positively associated with household poverty and worse nutritional indicators.<h4>Conclusions</h4>We found evidence of a role for low-grade inflammation in predicting annual BAZ gain among children aged >5 years.
format	article
author	Barbara H Lourenço Marly A Cardoso ACTION Study Team
author_facet	Barbara H Lourenço Marly A Cardoso ACTION Study Team
author_sort	Barbara H Lourenço
title	C-reactive protein concentration predicts change in body mass index during childhood.
title_short	C-reactive protein concentration predicts change in body mass index during childhood.
title_full	C-reactive protein concentration predicts change in body mass index during childhood.
title_fullStr	C-reactive protein concentration predicts change in body mass index during childhood.
title_full_unstemmed	C-reactive protein concentration predicts change in body mass index during childhood.
title_sort	c-reactive protein concentration predicts change in body mass index during childhood.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ccb224fa2a1f4b88b308d640967ccfa5
work_keys_str_mv	AT barbarahlourenco creactiveproteinconcentrationpredictschangeinbodymassindexduringchildhood AT marlyacardoso creactiveproteinconcentrationpredictschangeinbodymassindexduringchildhood AT actionstudyteam creactiveproteinconcentrationpredictschangeinbodymassindexduringchildhood
_version_	1718421772361007104

C-reactive protein concentration predicts change in body mass index during childhood.

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