Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S for Photothermal Cancer Cell Killing
A major challenge in cancer therapy is to achieve high cell targeting specificity for the highest therapeutic efficacy. Two major approaches have been shown to be quite effective, namely, (1) bio-marker mediated cell targeting, and (2) electrical charge driven cell binding. The former utilizes the t...
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MDPI AG
2021
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oai:doaj.org-article:ccb4170671e242ef94d05172217f7f342021-11-11T15:26:50ZDual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S for Photothermal Cancer Cell Killing10.3390/cancers132152752072-6694https://doaj.org/article/ccb4170671e242ef94d05172217f7f342021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5275https://doaj.org/toc/2072-6694A major challenge in cancer therapy is to achieve high cell targeting specificity for the highest therapeutic efficacy. Two major approaches have been shown to be quite effective, namely, (1) bio-marker mediated cell targeting, and (2) electrical charge driven cell binding. The former utilizes the tumor-specific moieties on nano carrier surfaces for active targeting, while the latter relies on nanoparticles binding onto the cancer cell surfaces due to differences in electrical charge. Cancer cells are known for their hallmark metabolic pattern: high rates of glycolysis that lead to negatively charged cell surfaces. In this study, the nanoparticles of Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S were rendered positively charged by conjugating their surfaces with different functional groups for strong electrostatic binding onto the negatively-charged cancer cells. In addition to the positively charged surfaces, the Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S nanoparticles were also modified with folic acid (FA) for biomarker-based cell targeting. The dual-targeting approach synergistically utilizes the effectiveness of both charge- and biomarker-based cell binding for enhanced cell targeting. Further, these superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S nanoparticles exhibit much stronger IR absorptions compared to Fe<sub>3</sub>O<sub>4</sub>, therefore much more effective in photothermal therapy.Zicheng DengJou LinSergey L. Bud’koBrent WebsterTanya V. KalinVladimir V. KalinichenkoDonglu ShiMDPI AGarticlesuperparamagnetic nanoparticlescancer cell photothermal therapysurface charge targetingfolic acid targetingvitamin E TPGS modificationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5275, p 5275 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
superparamagnetic nanoparticles cancer cell photothermal therapy surface charge targeting folic acid targeting vitamin E TPGS modification Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
superparamagnetic nanoparticles cancer cell photothermal therapy surface charge targeting folic acid targeting vitamin E TPGS modification Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zicheng Deng Jou Lin Sergey L. Bud’ko Brent Webster Tanya V. Kalin Vladimir V. Kalinichenko Donglu Shi Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S for Photothermal Cancer Cell Killing |
| description |
A major challenge in cancer therapy is to achieve high cell targeting specificity for the highest therapeutic efficacy. Two major approaches have been shown to be quite effective, namely, (1) bio-marker mediated cell targeting, and (2) electrical charge driven cell binding. The former utilizes the tumor-specific moieties on nano carrier surfaces for active targeting, while the latter relies on nanoparticles binding onto the cancer cell surfaces due to differences in electrical charge. Cancer cells are known for their hallmark metabolic pattern: high rates of glycolysis that lead to negatively charged cell surfaces. In this study, the nanoparticles of Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S were rendered positively charged by conjugating their surfaces with different functional groups for strong electrostatic binding onto the negatively-charged cancer cells. In addition to the positively charged surfaces, the Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S nanoparticles were also modified with folic acid (FA) for biomarker-based cell targeting. The dual-targeting approach synergistically utilizes the effectiveness of both charge- and biomarker-based cell binding for enhanced cell targeting. Further, these superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S nanoparticles exhibit much stronger IR absorptions compared to Fe<sub>3</sub>O<sub>4</sub>, therefore much more effective in photothermal therapy. |
| format |
article |
| author |
Zicheng Deng Jou Lin Sergey L. Bud’ko Brent Webster Tanya V. Kalin Vladimir V. Kalinichenko Donglu Shi |
| author_facet |
Zicheng Deng Jou Lin Sergey L. Bud’ko Brent Webster Tanya V. Kalin Vladimir V. Kalinichenko Donglu Shi |
| author_sort |
Zicheng Deng |
| title |
Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S for Photothermal Cancer Cell Killing |
| title_short |
Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S for Photothermal Cancer Cell Killing |
| title_full |
Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S for Photothermal Cancer Cell Killing |
| title_fullStr |
Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S for Photothermal Cancer Cell Killing |
| title_full_unstemmed |
Dual Targeting with Cell Surface Electrical Charge and Folic Acid via Superparamagnetic Fe<sub>3</sub>O<sub>4</sub>@Cu<sub>2–x</sub>S for Photothermal Cancer Cell Killing |
| title_sort |
dual targeting with cell surface electrical charge and folic acid via superparamagnetic fe<sub>3</sub>o<sub>4</sub>@cu<sub>2–x</sub>s for photothermal cancer cell killing |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/ccb4170671e242ef94d05172217f7f34 |
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