Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions

IP3 receptors mediate Ca2+ release from the endoplasmic reticulum. Here the authors show that only a small fraction of IP3 receptors initiate Ca2+ signals; these immobile IP3 receptors adjacent to the plasma membrane are optimally placed to control STIM1-dependent Ca2+ entry.

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Autores principales:	Nagendra Babu Thillaiappan, Alap P. Chavda, Stephen C. Tovey, David L. Prole, Colin W. Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccb66cca43dc44d68437d57d5d389ef9
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spelling	oai:doaj.org-article:ccb66cca43dc44d68437d57d5d389ef92021-12-02T13:24:34ZCa2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions10.1038/s41467-017-01644-82041-1723https://doaj.org/article/ccb66cca43dc44d68437d57d5d389ef92017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01644-8https://doaj.org/toc/2041-1723IP3 receptors mediate Ca2+ release from the endoplasmic reticulum. Here the authors show that only a small fraction of IP3 receptors initiate Ca2+ signals; these immobile IP3 receptors adjacent to the plasma membrane are optimally placed to control STIM1-dependent Ca2+ entry.Nagendra Babu ThillaiappanAlap P. ChavdaStephen C. ToveyDavid L. ProleColin W. TaylorNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nagendra Babu Thillaiappan Alap P. Chavda Stephen C. Tovey David L. Prole Colin W. Taylor Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
description	IP3 receptors mediate Ca2+ release from the endoplasmic reticulum. Here the authors show that only a small fraction of IP3 receptors initiate Ca2+ signals; these immobile IP3 receptors adjacent to the plasma membrane are optimally placed to control STIM1-dependent Ca2+ entry.
format	article
author	Nagendra Babu Thillaiappan Alap P. Chavda Stephen C. Tovey David L. Prole Colin W. Taylor
author_facet	Nagendra Babu Thillaiappan Alap P. Chavda Stephen C. Tovey David L. Prole Colin W. Taylor
author_sort	Nagendra Babu Thillaiappan
title	Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
title_short	Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
title_full	Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
title_fullStr	Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
title_full_unstemmed	Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
title_sort	ca2+ signals initiate at immobile ip3 receptors adjacent to er-plasma membrane junctions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ccb66cca43dc44d68437d57d5d389ef9
work_keys_str_mv	AT nagendrababuthillaiappan ca2signalsinitiateatimmobileip3receptorsadjacenttoerplasmamembranejunctions AT alappchavda ca2signalsinitiateatimmobileip3receptorsadjacenttoerplasmamembranejunctions AT stephenctovey ca2signalsinitiateatimmobileip3receptorsadjacenttoerplasmamembranejunctions AT davidlprole ca2signalsinitiateatimmobileip3receptorsadjacenttoerplasmamembranejunctions AT colinwtaylor ca2signalsinitiateatimmobileip3receptorsadjacenttoerplasmamembranejunctions
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Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions

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