Differences in candidate gene association between European ancestry and African American asthmatic children.
<h4>Background</h4>Candidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations fro...
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2011
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oai:doaj.org-article:ccb79b07379a45bcbabd5246bbd0edd72021-11-18T06:58:00ZDifferences in candidate gene association between European ancestry and African American asthmatic children.1932-620310.1371/journal.pone.0016522https://doaj.org/article/ccb79b07379a45bcbabd5246bbd0edd72011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21387019/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Candidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations from European ancestry. Recently, there is increasing interest in understanding racial differences in genetic risk associated with childhood asthma. Our aim was to compare association patterns of asthma candidate genes between children of European and African ancestry.<h4>Methodology/principal findings</h4>Using a custom-designed Illumina SNP array, we genotyped 1,485 children within the Greater Cincinnati Pediatric Clinic Repository and Cincinnati Genomic Control Cohort for 259 SNPs in 28 genes and evaluated their associations with asthma. We identified 14 SNPs located in 6 genes that were significantly associated (p-values <0.05) with childhood asthma in African Americans. Among Caucasians, 13 SNPs in 5 genes were associated with childhood asthma. Two SNPs in IL4 were associated with asthma in both races (p-values <0.05). Gene-gene interaction studies identified race specific sets of genes that best discriminate between asthmatic children and non-allergic controls.<h4>Conclusions/significance</h4>We identified IL4 as having a role in asthma susceptibility in both African American and Caucasian children. However, while IL4 SNPs were associated with asthma in asthmatic children with European and African ancestry, the relative contributions of the most replicated asthma-associated SNPs varied by ancestry. These data provides valuable insights into the pathways that may predispose to asthma in individuals with European vs. African ancestry.Tesfaye M BayeMelinda Butsch KovacicJocelyn M Biagini MyersLisa J MartinMark LindseyTia L PattersonHua HeMark B EricksenJayanta GuptaAnna M TsorasAndrew LindsleyMarc E RothenbergMarsha Wills-KarpN Tony EissaLarry BorishGurjit K Khurana HersheyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e16522 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Tesfaye M Baye Melinda Butsch Kovacic Jocelyn M Biagini Myers Lisa J Martin Mark Lindsey Tia L Patterson Hua He Mark B Ericksen Jayanta Gupta Anna M Tsoras Andrew Lindsley Marc E Rothenberg Marsha Wills-Karp N Tony Eissa Larry Borish Gurjit K Khurana Hershey Differences in candidate gene association between European ancestry and African American asthmatic children. |
| description |
<h4>Background</h4>Candidate gene case-control studies have identified several single nucleotide polymorphisms (SNPs) that are associated with asthma susceptibility. Most of these studies have been restricted to evaluations of specific SNPs within a single gene and within populations from European ancestry. Recently, there is increasing interest in understanding racial differences in genetic risk associated with childhood asthma. Our aim was to compare association patterns of asthma candidate genes between children of European and African ancestry.<h4>Methodology/principal findings</h4>Using a custom-designed Illumina SNP array, we genotyped 1,485 children within the Greater Cincinnati Pediatric Clinic Repository and Cincinnati Genomic Control Cohort for 259 SNPs in 28 genes and evaluated their associations with asthma. We identified 14 SNPs located in 6 genes that were significantly associated (p-values <0.05) with childhood asthma in African Americans. Among Caucasians, 13 SNPs in 5 genes were associated with childhood asthma. Two SNPs in IL4 were associated with asthma in both races (p-values <0.05). Gene-gene interaction studies identified race specific sets of genes that best discriminate between asthmatic children and non-allergic controls.<h4>Conclusions/significance</h4>We identified IL4 as having a role in asthma susceptibility in both African American and Caucasian children. However, while IL4 SNPs were associated with asthma in asthmatic children with European and African ancestry, the relative contributions of the most replicated asthma-associated SNPs varied by ancestry. These data provides valuable insights into the pathways that may predispose to asthma in individuals with European vs. African ancestry. |
| format |
article |
| author |
Tesfaye M Baye Melinda Butsch Kovacic Jocelyn M Biagini Myers Lisa J Martin Mark Lindsey Tia L Patterson Hua He Mark B Ericksen Jayanta Gupta Anna M Tsoras Andrew Lindsley Marc E Rothenberg Marsha Wills-Karp N Tony Eissa Larry Borish Gurjit K Khurana Hershey |
| author_facet |
Tesfaye M Baye Melinda Butsch Kovacic Jocelyn M Biagini Myers Lisa J Martin Mark Lindsey Tia L Patterson Hua He Mark B Ericksen Jayanta Gupta Anna M Tsoras Andrew Lindsley Marc E Rothenberg Marsha Wills-Karp N Tony Eissa Larry Borish Gurjit K Khurana Hershey |
| author_sort |
Tesfaye M Baye |
| title |
Differences in candidate gene association between European ancestry and African American asthmatic children. |
| title_short |
Differences in candidate gene association between European ancestry and African American asthmatic children. |
| title_full |
Differences in candidate gene association between European ancestry and African American asthmatic children. |
| title_fullStr |
Differences in candidate gene association between European ancestry and African American asthmatic children. |
| title_full_unstemmed |
Differences in candidate gene association between European ancestry and African American asthmatic children. |
| title_sort |
differences in candidate gene association between european ancestry and african american asthmatic children. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/ccb79b07379a45bcbabd5246bbd0edd7 |
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