The Activity of Plant Crude Extracts against Schistosoma mansoni

Background. Schistosoma mansoni remains a significant health problem in low-income countries. Praziquantel (PZQ) is the only drug available to treat schistosomiasis, and PZQ resistance is a potential threat towards control of the disease although PZQ is currently effective against all species of sch...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hirut Basha, Hassen Mamo
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ccc2d33e798e454b85b6deed5d0db6de
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ccc2d33e798e454b85b6deed5d0db6de
record_format	dspace
spelling	oai:doaj.org-article:ccc2d33e798e454b85b6deed5d0db6de2021-11-22T01:10:32ZThe Activity of Plant Crude Extracts against Schistosoma mansoni2090-003110.1155/2021/4397053https://doaj.org/article/ccc2d33e798e454b85b6deed5d0db6de2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4397053https://doaj.org/toc/2090-0031Background. Schistosoma mansoni remains a significant health problem in low-income countries. Praziquantel (PZQ) is the only drug available to treat schistosomiasis, and PZQ resistance is a potential threat towards control of the disease although PZQ is currently effective against all species of schistosomes. Moreover, PZQ is less efficacious against larval stages. In response to these challenges, multiple in vivo/in vitro studies evaluated the anti-S. mansoni activity of crude plant extracts in a bid for novel drug(s). However, these studies appear fragmented and patchy. This systematic review explored the extent of such studies in the past 11 years (2010-2020). Methods. A systematic web search analysis and review of the literature on crude plant extracts tested against S. mansoni was done. Data from 17 articles meeting eligibility criteria were extracted and analyzed. Forty-three plant species have been tested by the 17 studies. The leaves, barks, stems, flowers, rhizomes, and roots of the plants as well as the whole plant part were used for the experiments. Conclusion. Nearly all of the plants significantly reduced schistosome egg output, killed adult worms, and improved liver histology and function. Further studies are required to assess the therapeutic potential of more promising plant species.Hirut BashaHassen MamoHindawi LimitedarticleInfectious and parasitic diseasesRC109-216ENJournal of Parasitology Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216
spellingShingle	Infectious and parasitic diseases RC109-216 Hirut Basha Hassen Mamo The Activity of Plant Crude Extracts against Schistosoma mansoni
description	Background. Schistosoma mansoni remains a significant health problem in low-income countries. Praziquantel (PZQ) is the only drug available to treat schistosomiasis, and PZQ resistance is a potential threat towards control of the disease although PZQ is currently effective against all species of schistosomes. Moreover, PZQ is less efficacious against larval stages. In response to these challenges, multiple in vivo/in vitro studies evaluated the anti-S. mansoni activity of crude plant extracts in a bid for novel drug(s). However, these studies appear fragmented and patchy. This systematic review explored the extent of such studies in the past 11 years (2010-2020). Methods. A systematic web search analysis and review of the literature on crude plant extracts tested against S. mansoni was done. Data from 17 articles meeting eligibility criteria were extracted and analyzed. Forty-three plant species have been tested by the 17 studies. The leaves, barks, stems, flowers, rhizomes, and roots of the plants as well as the whole plant part were used for the experiments. Conclusion. Nearly all of the plants significantly reduced schistosome egg output, killed adult worms, and improved liver histology and function. Further studies are required to assess the therapeutic potential of more promising plant species.
format	article
author	Hirut Basha Hassen Mamo
author_facet	Hirut Basha Hassen Mamo
author_sort	Hirut Basha
title	The Activity of Plant Crude Extracts against Schistosoma mansoni
title_short	The Activity of Plant Crude Extracts against Schistosoma mansoni
title_full	The Activity of Plant Crude Extracts against Schistosoma mansoni
title_fullStr	The Activity of Plant Crude Extracts against Schistosoma mansoni
title_full_unstemmed	The Activity of Plant Crude Extracts against Schistosoma mansoni
title_sort	activity of plant crude extracts against schistosoma mansoni
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/ccc2d33e798e454b85b6deed5d0db6de
work_keys_str_mv	AT hirutbasha theactivityofplantcrudeextractsagainstschistosomamansoni AT hassenmamo theactivityofplantcrudeextractsagainstschistosomamansoni AT hirutbasha activityofplantcrudeextractsagainstschistosomamansoni AT hassenmamo activityofplantcrudeextractsagainstschistosomamansoni
_version_	1718418369297776640

The Activity of Plant Crude Extracts against Schistosoma mansoni

Ejemplares similares