CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-ce...
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Nature Portfolio
2021
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oai:doaj.org-article:ccc6ff85f88e4afdb0a9c7be290f2a3b2021-12-02T14:10:56ZCAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy10.1038/s41467-021-20893-22041-1723https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20893-2https://doaj.org/toc/2041-1723Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-cell therapy in pre-clinical models.Alba Rodriguez-GarciaRachel C. LynnMathilde PoussinMonika A. EivaLauren C. ShawRoddy S. O’ConnorNicholas G. MinutoloVictoria Casado-MedranoGonzalo LopezTakami MatsuyamaDaniel J. PowellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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Science Q Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy |
description |
Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-cell therapy in pre-clinical models. |
format |
article |
author |
Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell |
author_facet |
Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell |
author_sort |
Alba Rodriguez-Garcia |
title |
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy |
title_short |
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy |
title_full |
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy |
title_fullStr |
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy |
title_full_unstemmed |
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy |
title_sort |
car-t cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b |
work_keys_str_mv |
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