CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-ce...

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Autores principales: Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b
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spelling oai:doaj.org-article:ccc6ff85f88e4afdb0a9c7be290f2a3b2021-12-02T14:10:56ZCAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy10.1038/s41467-021-20893-22041-1723https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20893-2https://doaj.org/toc/2041-1723Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-cell therapy in pre-clinical models.Alba Rodriguez-GarciaRachel C. LynnMathilde PoussinMonika A. EivaLauren C. ShawRoddy S. O’ConnorNicholas G. MinutoloVictoria Casado-MedranoGonzalo LopezTakami MatsuyamaDaniel J. PowellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alba Rodriguez-Garcia
Rachel C. Lynn
Mathilde Poussin
Monika A. Eiva
Lauren C. Shaw
Roddy S. O’Connor
Nicholas G. Minutolo
Victoria Casado-Medrano
Gonzalo Lopez
Takami Matsuyama
Daniel J. Powell
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
description Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-cell therapy in pre-clinical models.
format article
author Alba Rodriguez-Garcia
Rachel C. Lynn
Mathilde Poussin
Monika A. Eiva
Lauren C. Shaw
Roddy S. O’Connor
Nicholas G. Minutolo
Victoria Casado-Medrano
Gonzalo Lopez
Takami Matsuyama
Daniel J. Powell
author_facet Alba Rodriguez-Garcia
Rachel C. Lynn
Mathilde Poussin
Monika A. Eiva
Lauren C. Shaw
Roddy S. O’Connor
Nicholas G. Minutolo
Victoria Casado-Medrano
Gonzalo Lopez
Takami Matsuyama
Daniel J. Powell
author_sort Alba Rodriguez-Garcia
title CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_short CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_full CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_fullStr CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_full_unstemmed CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_sort car-t cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b
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