CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-ce...

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Autores principales:	Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b
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spelling	oai:doaj.org-article:ccc6ff85f88e4afdb0a9c7be290f2a3b2021-12-02T14:10:56ZCAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy10.1038/s41467-021-20893-22041-1723https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20893-2https://doaj.org/toc/2041-1723Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-cell therapy in pre-clinical models.Alba Rodriguez-GarciaRachel C. LynnMathilde PoussinMonika A. EivaLauren C. ShawRoddy S. O’ConnorNicholas G. MinutoloVictoria Casado-MedranoGonzalo LopezTakami MatsuyamaDaniel J. PowellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
description	Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endogenous antitumor immune responses and adoptive T-cell therapy in pre-clinical models.
format	article
author	Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell
author_facet	Alba Rodriguez-Garcia Rachel C. Lynn Mathilde Poussin Monika A. Eiva Lauren C. Shaw Roddy S. O’Connor Nicholas G. Minutolo Victoria Casado-Medrano Gonzalo Lopez Takami Matsuyama Daniel J. Powell
author_sort	Alba Rodriguez-Garcia
title	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_short	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_full	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_fullStr	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_full_unstemmed	CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
title_sort	car-t cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b
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CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

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