Vaccination with Recombinant <italic toggle="yes">Cryptococcus</italic> Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species

Vaccination with Recombinant <italic toggle="yes">Cryptococcus</italic> Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species

ABSTRACT Development of a vaccine to protect against cryptococcosis is a priority given the enormous global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery system, we previously demonstrated that mice vaccinated with crude Cryptococcus-derived alkaline extracts w...

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Autores principales: Charles A. Specht, Chrono K. Lee, Haibin Huang, Maureen M. Hester, Jianhua Liu, Bridget A. Luckie, Melanie A. Torres Santana, Zeynep Mirza, Payam Khoshkenar, Ambily Abraham, Zu T. Shen, Jennifer K. Lodge, Ali Akalin, Jane Homan, Gary R. Ostroff, Stuart M. Levitz
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Cryptococcus
bioinformatics
glucans
immunization
major histocompatibility complex
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/ccc77c9aab1b4f15ad727746a758c049
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