Oxidative stress markers in patients with hereditary angioedema

Introduction Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) or with normal C1-INH is characterized by recurrent swellings due to uncontrolled production of vasoactive mediators, among which bradykinin (BK) is crucial. Through the binding and activation of the two human BK-receptors, kin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stefano R. Del Giacco, Davide Firinu, Paola Lucia Minciullo, Maria Pina Barca, Paolo Emilio Manconi, Gennaro Tartarisco, Mariateresa Cristani, Antonella Saija, Sebastiano Gangemi
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	hereditary angioedema c1-inhibitor bradykinin oxidative stress kinin hae Medicine R
Acceso en línea:	https://doaj.org/article/ccc8f5c526b3494db8b01fd95e5004e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ccc8f5c526b3494db8b01fd95e5004e8
record_format	dspace
spelling	oai:doaj.org-article:ccc8f5c526b3494db8b01fd95e5004e82021-12-02T19:15:49ZOxidative stress markers in patients with hereditary angioedema1734-19221896-915110.5114/aoms.2017.66160https://doaj.org/article/ccc8f5c526b3494db8b01fd95e5004e82018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Oxidative-stress-markers-in-patients-with-hereditary-angioedema,68562,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) or with normal C1-INH is characterized by recurrent swellings due to uncontrolled production of vasoactive mediators, among which bradykinin (BK) is crucial. Through the binding and activation of the two human BK-receptors, kinins may have dual beneficial and deleterious effects in vascular and inflammation physiopathology by inducing oxidative stress. We aimed to assess the serum concentrations of advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) in patients affected by HAE. Material and methods Blood samples were collected to measure the serum concentrations of AGEs and AOPPs by spectrofluorimetric and spectrophotometric methods in patients affected by C1-INH-HAE and FXII-HAE during the remission state. Results We showed that the circulating levels of AOPPs observed on control group (0.94 (0.36) nmol/mg) were significantly lower than those observed on the C1-INH-HAE group (1.68 (0.47) nmol/mg; p = 0.002) and FXII-HAE (1.50 (0.27) nmol/mg; p = 0.001). Moreover, the circulating levels of AGEs were significantly higher in C1-INH-HAE group (211.58 (151.05) AU/g; p = 0.02) than the FXII group (141.48 (89.59) AU/g), thus demonstrating a state of heightened oxidative stress. Conclusions Our observations show additional underlying events involved in HAE and are of central importance for further investigations of differences in bradykinin receptors signaling among the two disease subgroups.Stefano R. Del GiaccoDavide FirinuPaola Lucia MinciulloMaria Pina BarcaPaolo Emilio ManconiGennaro TartariscoMariateresa CristaniAntonella SaijaSebastiano GangemiTermedia Publishing Housearticlehereditary angioedemac1-inhibitorbradykininoxidative stresskininhaehereditary angioedemaoxidative stressMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 92-98 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	hereditary angioedema c1-inhibitor bradykinin oxidative stress kinin hae hereditary angioedema oxidative stress Medicine R
spellingShingle	hereditary angioedema c1-inhibitor bradykinin oxidative stress kinin hae hereditary angioedema oxidative stress Medicine R Stefano R. Del Giacco Davide Firinu Paola Lucia Minciullo Maria Pina Barca Paolo Emilio Manconi Gennaro Tartarisco Mariateresa Cristani Antonella Saija Sebastiano Gangemi Oxidative stress markers in patients with hereditary angioedema
description	Introduction Hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) or with normal C1-INH is characterized by recurrent swellings due to uncontrolled production of vasoactive mediators, among which bradykinin (BK) is crucial. Through the binding and activation of the two human BK-receptors, kinins may have dual beneficial and deleterious effects in vascular and inflammation physiopathology by inducing oxidative stress. We aimed to assess the serum concentrations of advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) in patients affected by HAE. Material and methods Blood samples were collected to measure the serum concentrations of AGEs and AOPPs by spectrofluorimetric and spectrophotometric methods in patients affected by C1-INH-HAE and FXII-HAE during the remission state. Results We showed that the circulating levels of AOPPs observed on control group (0.94 (0.36) nmol/mg) were significantly lower than those observed on the C1-INH-HAE group (1.68 (0.47) nmol/mg; p = 0.002) and FXII-HAE (1.50 (0.27) nmol/mg; p = 0.001). Moreover, the circulating levels of AGEs were significantly higher in C1-INH-HAE group (211.58 (151.05) AU/g; p = 0.02) than the FXII group (141.48 (89.59) AU/g), thus demonstrating a state of heightened oxidative stress. Conclusions Our observations show additional underlying events involved in HAE and are of central importance for further investigations of differences in bradykinin receptors signaling among the two disease subgroups.
format	article
author	Stefano R. Del Giacco Davide Firinu Paola Lucia Minciullo Maria Pina Barca Paolo Emilio Manconi Gennaro Tartarisco Mariateresa Cristani Antonella Saija Sebastiano Gangemi
author_facet	Stefano R. Del Giacco Davide Firinu Paola Lucia Minciullo Maria Pina Barca Paolo Emilio Manconi Gennaro Tartarisco Mariateresa Cristani Antonella Saija Sebastiano Gangemi
author_sort	Stefano R. Del Giacco
title	Oxidative stress markers in patients with hereditary angioedema
title_short	Oxidative stress markers in patients with hereditary angioedema
title_full	Oxidative stress markers in patients with hereditary angioedema
title_fullStr	Oxidative stress markers in patients with hereditary angioedema
title_full_unstemmed	Oxidative stress markers in patients with hereditary angioedema
title_sort	oxidative stress markers in patients with hereditary angioedema
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/ccc8f5c526b3494db8b01fd95e5004e8
work_keys_str_mv	AT stefanordelgiacco oxidativestressmarkersinpatientswithhereditaryangioedema AT davidefirinu oxidativestressmarkersinpatientswithhereditaryangioedema AT paolaluciaminciullo oxidativestressmarkersinpatientswithhereditaryangioedema AT mariapinabarca oxidativestressmarkersinpatientswithhereditaryangioedema AT paoloemiliomanconi oxidativestressmarkersinpatientswithhereditaryangioedema AT gennarotartarisco oxidativestressmarkersinpatientswithhereditaryangioedema AT mariateresacristani oxidativestressmarkersinpatientswithhereditaryangioedema AT antonellasaija oxidativestressmarkersinpatientswithhereditaryangioedema AT sebastianogangemi oxidativestressmarkersinpatientswithhereditaryangioedema
_version_	1718376997757911040

Oxidative stress markers in patients with hereditary angioedema

Ejemplares similares