When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α,ω-diols in Pseudomonas putida KT2440

When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α,ω-diols in Pseudomonas putida KT2440

Abstract Background Medium-chain-length α,ω-diols (mcl-diols) are important building blocks in polymer production. Recently, microbial mcl-diol production from alkanes was achieved in E. coli (albeit at low rates) using the alkane monooxygenase system AlkBGTL and esterification module Atf1. Owing to...

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Bibliographic Details
Main Authors: Chunzhe Lu, Christos Batianis, Edward Ofori Akwafo, Rene H. Wijffels, Vitor A. P. Martins dos Santos, Ruud A. Weusthuis
Format: article
Language:EN
Published: BMC 2021
Subjects:
Metabolic versatility
Substrate preference
Monooxygenase
Medium-chain-length α,ω-diols
ω-Oxyfunctionalization
Pseudomonas putida
Fuel
TP315-360
Biotechnology
TP248.13-248.65
Online Access:https://doaj.org/article/cccab6659f2b4e9f97c37ef1498f1577
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https://doaj.org/article/cccab6659f2b4e9f97c37ef1498f1577

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