Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells

Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells

Abstract The Hippo signaling pathway is involved in organ size regulation and tumor suppression. Although inhibition of Hippo leads to tumorigenesis, activation of Hippo may play a role in neurodegeneration. Specifically, activation of the upstream regulator, mammalian sterile 20 (STE20)-like kinase...

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Main Authors: Kaly A. Mueller, Kelly E. Glajch, Megan N. Huizenga, Remi A. Wilson, Eric J. Granucci, Amanda M. Dios, Adelaide R. Tousley, Maria Iuliano, Elizabeth Weisman, Michael J. LaQuaglia, Marian DiFiglia, Kimberly Kegel-Gleason, Khashayar Vakili, Ghazaleh Sadri-Vakili
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/cccd0dab16664adfba16dc950c90aec9
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https://doaj.org/article/cccd0dab16664adfba16dc950c90aec9

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