Sex differences in the impact of childhood socioeconomic status on immune function

Abstract Early life stress increases one’s risk for health problems later in life, and many studies find that these effects are sex-differentiated. Here, we examined relationships between multiple sources of early life stress and adult immune function in humans across several functional assays. Adul...

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Autores principales:	Jeffrey Gassen, Jordon D. White, Julia L. Peterman, Summer Mengelkoch, Randi P. Proffitt Leyva, Marjorie L. Prokosch, Micah J. Eimerbrink, Kelly Brice, Dennis J. Cheek, Gary W. Boehm, Sarah E. Hill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cccd8fed0019430ba07c2a7b80296a27
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spelling	oai:doaj.org-article:cccd8fed0019430ba07c2a7b80296a272021-12-02T14:35:34ZSex differences in the impact of childhood socioeconomic status on immune function10.1038/s41598-021-89413-y2045-2322https://doaj.org/article/cccd8fed0019430ba07c2a7b80296a272021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89413-yhttps://doaj.org/toc/2045-2322Abstract Early life stress increases one’s risk for health problems later in life, and many studies find that these effects are sex-differentiated. Here, we examined relationships between multiple sources of early life stress and adult immune function in humans across several functional assays. Adult participants provided retrospective information about their childhood (a) socioeconomic status, (b) household unpredictability, and (c) exposure to adverse experiences. Participants’ peripheral blood mononuclear cells (PBMCs) were then isolated for use in functional assays of immune performance: (a) tumor cell lysis by natural killer cells, (b) phagocytosis of Escherichia coli bioparticles, and (c) mitogen-induced leukocyte proliferation and cytokine release. In men, lower childhood socioeconomic status predicted decrements in immunological performance across functional assays, along with greater spontaneous cytokine release from PBMCs. These changes co-occurred with elevations in plasma testosterone levels. Similar effects were not observed for other sources of stress, nor were they found in women (with the exception of spontaneous cytokine release). These findings provide evidence that low childhood socioeconomic status has a lasting negative impact on multiple aspects of immune function, particularly in men.Jeffrey GassenJordon D. WhiteJulia L. PetermanSummer MengelkochRandi P. Proffitt LeyvaMarjorie L. ProkoschMicah J. EimerbrinkKelly BriceDennis J. CheekGary W. BoehmSarah E. HillNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeffrey Gassen Jordon D. White Julia L. Peterman Summer Mengelkoch Randi P. Proffitt Leyva Marjorie L. Prokosch Micah J. Eimerbrink Kelly Brice Dennis J. Cheek Gary W. Boehm Sarah E. Hill Sex differences in the impact of childhood socioeconomic status on immune function
description	Abstract Early life stress increases one’s risk for health problems later in life, and many studies find that these effects are sex-differentiated. Here, we examined relationships between multiple sources of early life stress and adult immune function in humans across several functional assays. Adult participants provided retrospective information about their childhood (a) socioeconomic status, (b) household unpredictability, and (c) exposure to adverse experiences. Participants’ peripheral blood mononuclear cells (PBMCs) were then isolated for use in functional assays of immune performance: (a) tumor cell lysis by natural killer cells, (b) phagocytosis of Escherichia coli bioparticles, and (c) mitogen-induced leukocyte proliferation and cytokine release. In men, lower childhood socioeconomic status predicted decrements in immunological performance across functional assays, along with greater spontaneous cytokine release from PBMCs. These changes co-occurred with elevations in plasma testosterone levels. Similar effects were not observed for other sources of stress, nor were they found in women (with the exception of spontaneous cytokine release). These findings provide evidence that low childhood socioeconomic status has a lasting negative impact on multiple aspects of immune function, particularly in men.
format	article
author	Jeffrey Gassen Jordon D. White Julia L. Peterman Summer Mengelkoch Randi P. Proffitt Leyva Marjorie L. Prokosch Micah J. Eimerbrink Kelly Brice Dennis J. Cheek Gary W. Boehm Sarah E. Hill
author_facet	Jeffrey Gassen Jordon D. White Julia L. Peterman Summer Mengelkoch Randi P. Proffitt Leyva Marjorie L. Prokosch Micah J. Eimerbrink Kelly Brice Dennis J. Cheek Gary W. Boehm Sarah E. Hill
author_sort	Jeffrey Gassen
title	Sex differences in the impact of childhood socioeconomic status on immune function
title_short	Sex differences in the impact of childhood socioeconomic status on immune function
title_full	Sex differences in the impact of childhood socioeconomic status on immune function
title_fullStr	Sex differences in the impact of childhood socioeconomic status on immune function
title_full_unstemmed	Sex differences in the impact of childhood socioeconomic status on immune function
title_sort	sex differences in the impact of childhood socioeconomic status on immune function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cccd8fed0019430ba07c2a7b80296a27
work_keys_str_mv	AT jeffreygassen sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT jordondwhite sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT julialpeterman sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT summermengelkoch sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT randipproffittleyva sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT marjorielprokosch sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT micahjeimerbrink sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT kellybrice sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT dennisjcheek sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT garywboehm sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction AT sarahehill sexdifferencesintheimpactofchildhoodsocioeconomicstatusonimmunefunction
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Sex differences in the impact of childhood socioeconomic status on immune function

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