CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE

A group of 112 patients with chronic obstructive pulmonary disease of severity were included into the study. Differential cell counts, IL-8, TNFα, and IL-10 concentrations were assayed in sputum and bronchial lavage. The results were compared in groups with different severity of the disease. High le...

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Autores principales:	L. Yu. Dolinina, A. N. Delievа, E. O. Bogdanovа, O. V. Galkina, V. I. Trofimov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	copd inflammation il-8 tnfα il -10 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ccd0048d95b547fea6e99c82c7b753c5
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spelling	oai:doaj.org-article:ccd0048d95b547fea6e99c82c7b753c52021-11-18T08:03:37ZCHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE1563-06252313-741X10.15789/1563-0625-2013-2-141-146https://doaj.org/article/ccd0048d95b547fea6e99c82c7b753c52014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/92https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XA group of 112 patients with chronic obstructive pulmonary disease of severity were included into the study. Differential cell counts, IL-8, TNFα, and IL-10 concentrations were assayed in sputum and bronchial lavage. The results were compared in groups with different severity of the disease. High levels of macrophages in sputum and bronchial lavage were revealed in COPD of grade 1 and 2. More severe COPD was characterized by mean higher levels of neutrophils in sputum and bronchial lavage. Increased levels of IL-8 and TNFα cytokines have been found in bronchial secretions, independently on COPD severity. Interestingly, maximal levels of these cytokines were associated with mild /moderate stage of the disorder. We have confirmed distinct effects of inhaled corticosteroids upon cytokine levels in sputum and bronchial lavage samples. Sputum proved to be a useful biological material for studies of local inflammatory events in COPD.L. Yu. DolininaA. N. DelievаE. O. BogdanovаO. V. GalkinaV. I. TrofimovSPb RAACIarticlecopdinflammationil-8tnfαil -10Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 2, Pp 141-146 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	copd inflammation il-8 tnfα il -10 Immunologic diseases. Allergy RC581-607
spellingShingle	copd inflammation il-8 tnfα il -10 Immunologic diseases. Allergy RC581-607 L. Yu. Dolinina A. N. Delievа E. O. Bogdanovа O. V. Galkina V. I. Trofimov CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE
description	A group of 112 patients with chronic obstructive pulmonary disease of severity were included into the study. Differential cell counts, IL-8, TNFα, and IL-10 concentrations were assayed in sputum and bronchial lavage. The results were compared in groups with different severity of the disease. High levels of macrophages in sputum and bronchial lavage were revealed in COPD of grade 1 and 2. More severe COPD was characterized by mean higher levels of neutrophils in sputum and bronchial lavage. Increased levels of IL-8 and TNFα cytokines have been found in bronchial secretions, independently on COPD severity. Interestingly, maximal levels of these cytokines were associated with mild /moderate stage of the disorder. We have confirmed distinct effects of inhaled corticosteroids upon cytokine levels in sputum and bronchial lavage samples. Sputum proved to be a useful biological material for studies of local inflammatory events in COPD.
format	article
author	L. Yu. Dolinina A. N. Delievа E. O. Bogdanovа O. V. Galkina V. I. Trofimov
author_facet	L. Yu. Dolinina A. N. Delievа E. O. Bogdanovа O. V. Galkina V. I. Trofimov
author_sort	L. Yu. Dolinina
title	CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE
title_short	CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE
title_full	CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE
title_fullStr	CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE
title_full_unstemmed	CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE
title_sort	characteristics of local inflammation in chronic obstructive pulmonary disease: dependence on severity stage
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ccd0048d95b547fea6e99c82c7b753c5
work_keys_str_mv	AT lyudolinina characteristicsoflocalinflammationinchronicobstructivepulmonarydiseasedependenceonseveritystage AT andelieva characteristicsoflocalinflammationinchronicobstructivepulmonarydiseasedependenceonseveritystage AT eobogdanova characteristicsoflocalinflammationinchronicobstructivepulmonarydiseasedependenceonseveritystage AT ovgalkina characteristicsoflocalinflammationinchronicobstructivepulmonarydiseasedependenceonseveritystage AT vitrofimov characteristicsoflocalinflammationinchronicobstructivepulmonarydiseasedependenceonseveritystage
_version_	1718422568488140800

CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE

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