Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma

Most low-grade oral epithelial dysplasia remains static or regress, but a significant minority of them (4–11%) advances to oral squamous cell carcinoma (OSCC) within a few years. To monitor the progression of epithelial dysplasia for early cancer detection, we investigated the expression profiles of...

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Autores principales:	Madeleine Crawford, Xiaoqin Liu, Yi-Shing L Cheng, Robert YL Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cancer prevention Leukoplakia Oral epithelial dysplasia Oral premalignant lesion Prognosis prediction Risk assessment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ccd3ac65e9bc49a79b91380b68dc35c1
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spelling	oai:doaj.org-article:ccd3ac65e9bc49a79b91380b68dc35c12021-11-30T04:14:38ZNucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma1476-558610.1016/j.neo.2021.11.001https://doaj.org/article/ccd3ac65e9bc49a79b91380b68dc35c12021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1476558621000920https://doaj.org/toc/1476-5586Most low-grade oral epithelial dysplasia remains static or regress, but a significant minority of them (4–11%) advances to oral squamous cell carcinoma (OSCC) within a few years. To monitor the progression of epithelial dysplasia for early cancer detection, we investigated the expression profiles of nucleostemin (NS) and phospho-STAT3 (p-STAT3) in rodent and human samples of dysplasia and OSCCs. In a 4NQO-induced rat oral carcinogenesis model, the number and distribution of NS and p-STAT3-positive cells increased in hyperplastic, dysplastic, and neoplastic lesions compared to normal epithelium. In human samples, the NS signal significantly increased in high-grade dysplasia and poorly differentiated OSCC, whereas p-STAT3 was more ubiquitously expressed than NS and showed increased intensity in high-grade dysplasia and both well and poorly differentiated OSCC. Analyses of human dysplastic samples with longitudinally followed outcomes revealed that cells with prominent nucleolar NS signals were more abundant in low-grade dysplasia that advanced to OSCC in 2 or 3 years than those remaining static for 7–14 years. These results suggest that NS upregulation and STAT3 activation are early events in the progression of low-grade dysplasia to OSCC.Madeleine CrawfordXiaoqin LiuYi-Shing L ChengRobert YL TsaiElsevierarticleCancer preventionLeukoplakiaOral epithelial dysplasiaOral premalignant lesionPrognosis predictionRisk assessmentNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENNeoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1289-1299 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer prevention Leukoplakia Oral epithelial dysplasia Oral premalignant lesion Prognosis prediction Risk assessment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Cancer prevention Leukoplakia Oral epithelial dysplasia Oral premalignant lesion Prognosis prediction Risk assessment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Madeleine Crawford Xiaoqin Liu Yi-Shing L Cheng Robert YL Tsai Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma
description	Most low-grade oral epithelial dysplasia remains static or regress, but a significant minority of them (4–11%) advances to oral squamous cell carcinoma (OSCC) within a few years. To monitor the progression of epithelial dysplasia for early cancer detection, we investigated the expression profiles of nucleostemin (NS) and phospho-STAT3 (p-STAT3) in rodent and human samples of dysplasia and OSCCs. In a 4NQO-induced rat oral carcinogenesis model, the number and distribution of NS and p-STAT3-positive cells increased in hyperplastic, dysplastic, and neoplastic lesions compared to normal epithelium. In human samples, the NS signal significantly increased in high-grade dysplasia and poorly differentiated OSCC, whereas p-STAT3 was more ubiquitously expressed than NS and showed increased intensity in high-grade dysplasia and both well and poorly differentiated OSCC. Analyses of human dysplastic samples with longitudinally followed outcomes revealed that cells with prominent nucleolar NS signals were more abundant in low-grade dysplasia that advanced to OSCC in 2 or 3 years than those remaining static for 7–14 years. These results suggest that NS upregulation and STAT3 activation are early events in the progression of low-grade dysplasia to OSCC.
format	article
author	Madeleine Crawford Xiaoqin Liu Yi-Shing L Cheng Robert YL Tsai
author_facet	Madeleine Crawford Xiaoqin Liu Yi-Shing L Cheng Robert YL Tsai
author_sort	Madeleine Crawford
title	Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma
title_short	Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma
title_full	Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma
title_fullStr	Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma
title_full_unstemmed	Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma
title_sort	nucleostemin upregulation and stat3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ccd3ac65e9bc49a79b91380b68dc35c1
work_keys_str_mv	AT madeleinecrawford nucleosteminupregulationandstat3activationasearlyeventsinoralepithelialdysplasiaprogressiontosquamouscellcarcinoma AT xiaoqinliu nucleosteminupregulationandstat3activationasearlyeventsinoralepithelialdysplasiaprogressiontosquamouscellcarcinoma AT yishinglcheng nucleosteminupregulationandstat3activationasearlyeventsinoralepithelialdysplasiaprogressiontosquamouscellcarcinoma AT robertyltsai nucleosteminupregulationandstat3activationasearlyeventsinoralepithelialdysplasiaprogressiontosquamouscellcarcinoma
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Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma

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