Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases

Over the last decades, the frequency of allergic disorders has steadily increased. Immunologically, allergies are caused by abnormal immune responses directed against otherwise harmless antigens derived from our environment. Two of the main cell types driving allergic sensitization and inflammation...

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Autores principales:	Yen-Ju Lin, Alexandra Goretzki, Stefan Schülke
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	allergies metabolism glycolysis immune metabolism oxidative phosphorylation fatty acid oxidation (FAO) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ccd533471bb74622b3e2faf057f5a9e0
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id	oai:doaj.org-article:ccd533471bb74622b3e2faf057f5a9e0
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spelling	oai:doaj.org-article:ccd533471bb74622b3e2faf057f5a9e02021-12-01T23:14:04ZImmune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases1664-322410.3389/fimmu.2021.790658https://doaj.org/article/ccd533471bb74622b3e2faf057f5a9e02021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.790658/fullhttps://doaj.org/toc/1664-3224Over the last decades, the frequency of allergic disorders has steadily increased. Immunologically, allergies are caused by abnormal immune responses directed against otherwise harmless antigens derived from our environment. Two of the main cell types driving allergic sensitization and inflammation are IgE-producing plasma cells and Th2 cells. The acute activation of T and B cells, their differentiation into effector cells, as well as the formation of immunological memory are paralleled by distinct changes in cellular metabolism. Understanding the functional consequences of these metabolic changes is the focus of a new research field termed “immune metabolism”. Currently, the contribution of metabolic changes in T and B cells to either the development or maintenance of allergies is not completely understood. Therefore, this mini review will introduce the fundamentals of energy metabolism, its connection to immune metabolism, and subsequently focus on the metabolic phenotypes of IL-4-activated B cells and Th2 cells.Yen-Ju LinAlexandra GoretzkiStefan SchülkeFrontiers Media S.A.articleallergiesmetabolismglycolysisimmune metabolismoxidative phosphorylationfatty acid oxidation (FAO)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	allergies metabolism glycolysis immune metabolism oxidative phosphorylation fatty acid oxidation (FAO) Immunologic diseases. Allergy RC581-607
spellingShingle	allergies metabolism glycolysis immune metabolism oxidative phosphorylation fatty acid oxidation (FAO) Immunologic diseases. Allergy RC581-607 Yen-Ju Lin Alexandra Goretzki Stefan Schülke Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases
description	Over the last decades, the frequency of allergic disorders has steadily increased. Immunologically, allergies are caused by abnormal immune responses directed against otherwise harmless antigens derived from our environment. Two of the main cell types driving allergic sensitization and inflammation are IgE-producing plasma cells and Th2 cells. The acute activation of T and B cells, their differentiation into effector cells, as well as the formation of immunological memory are paralleled by distinct changes in cellular metabolism. Understanding the functional consequences of these metabolic changes is the focus of a new research field termed “immune metabolism”. Currently, the contribution of metabolic changes in T and B cells to either the development or maintenance of allergies is not completely understood. Therefore, this mini review will introduce the fundamentals of energy metabolism, its connection to immune metabolism, and subsequently focus on the metabolic phenotypes of IL-4-activated B cells and Th2 cells.
format	article
author	Yen-Ju Lin Alexandra Goretzki Stefan Schülke
author_facet	Yen-Ju Lin Alexandra Goretzki Stefan Schülke
author_sort	Yen-Ju Lin
title	Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases
title_short	Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases
title_full	Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases
title_fullStr	Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases
title_full_unstemmed	Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases
title_sort	immune metabolism of il-4-activated b cells and th2 cells in the context of allergic diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ccd533471bb74622b3e2faf057f5a9e0
work_keys_str_mv	AT yenjulin immunemetabolismofil4activatedbcellsandth2cellsinthecontextofallergicdiseases AT alexandragoretzki immunemetabolismofil4activatedbcellsandth2cellsinthecontextofallergicdiseases AT stefanschulke immunemetabolismofil4activatedbcellsandth2cellsinthecontextofallergicdiseases
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Immune Metabolism of IL-4-Activated B Cells and Th2 Cells in the Context of Allergic Diseases

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