Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis

Abstract Toll-like receptors (TLRs) recognise microbes that contribute to the severity of bronchiolitis and the subsequent risk of asthma. We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187...

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Autores principales:	Sari Törmänen, Matti Korppi, Johanna Teräsjärvi, Juho Vuononvirta, Petri Koponen, Merja Helminen, Qiushui He, Kirsi Nuolivirta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ccd67b4332b1487e93909ba9c7e36725
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spelling	oai:doaj.org-article:ccd67b4332b1487e93909ba9c7e367252021-12-02T12:30:19ZPolymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis10.1038/s41598-017-03429-x2045-2322https://doaj.org/article/ccd67b4332b1487e93909ba9c7e367252017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03429-xhttps://doaj.org/toc/2045-2322Abstract Toll-like receptors (TLRs) recognise microbes that contribute to the severity of bronchiolitis and the subsequent risk of asthma. We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 genes. The gene polymorphisms were studied at the age of 6.4 years (mean) in 135 children hospitalised for bronchiolitis in infancy. The outcome measure was current or previous asthma. Current asthma was more common (30%) in children with the variant AG or GG genotype in the TLR10 rs4129009 gene versus those who were homozygous for the major allele A (11%) (p = 0.03). The adjusted odds ratio (aOR) was 4.30 (95% CI 1.30–14.29). Asthma ever was more common (34.6%) in girls with the TLR7 variant AT or TT genotype versus those who were homozygous for the major allele A (12.5%) (p = 0.03). The adjusted OR was 3.93 (95% CI 1.06–14.58). Corresponding associations were not seen in boys. There were no significant associations between TLR3, TLR4, TLR8, or TLR9 polymorphisms and post-bronchiolitis asthma. Polymorphism in the TLR10 gene increases and in the TLR7 gene may increase the risk of asthma in preschool-aged children after infant bronchiolitis.Sari TörmänenMatti KorppiJohanna TeräsjärviJuho VuononvirtaPetri KoponenMerja HelminenQiushui HeKirsi NuolivirtaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sari Törmänen Matti Korppi Johanna Teräsjärvi Juho Vuononvirta Petri Koponen Merja Helminen Qiushui He Kirsi Nuolivirta Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis
description	Abstract Toll-like receptors (TLRs) recognise microbes that contribute to the severity of bronchiolitis and the subsequent risk of asthma. We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 genes. The gene polymorphisms were studied at the age of 6.4 years (mean) in 135 children hospitalised for bronchiolitis in infancy. The outcome measure was current or previous asthma. Current asthma was more common (30%) in children with the variant AG or GG genotype in the TLR10 rs4129009 gene versus those who were homozygous for the major allele A (11%) (p = 0.03). The adjusted odds ratio (aOR) was 4.30 (95% CI 1.30–14.29). Asthma ever was more common (34.6%) in girls with the TLR7 variant AT or TT genotype versus those who were homozygous for the major allele A (12.5%) (p = 0.03). The adjusted OR was 3.93 (95% CI 1.06–14.58). Corresponding associations were not seen in boys. There were no significant associations between TLR3, TLR4, TLR8, or TLR9 polymorphisms and post-bronchiolitis asthma. Polymorphism in the TLR10 gene increases and in the TLR7 gene may increase the risk of asthma in preschool-aged children after infant bronchiolitis.
format	article
author	Sari Törmänen Matti Korppi Johanna Teräsjärvi Juho Vuononvirta Petri Koponen Merja Helminen Qiushui He Kirsi Nuolivirta
author_facet	Sari Törmänen Matti Korppi Johanna Teräsjärvi Juho Vuononvirta Petri Koponen Merja Helminen Qiushui He Kirsi Nuolivirta
author_sort	Sari Törmänen
title	Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis
title_short	Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis
title_full	Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis
title_fullStr	Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis
title_full_unstemmed	Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis
title_sort	polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ccd67b4332b1487e93909ba9c7e36725
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Polymorphism in the gene encoding toll-like receptor 10 may be associated with asthma after bronchiolitis

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