C-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE

Objective: To determine C-reactive protein kinetics in term and preterm babies with early onset sepsis and its association with blood culture. Study Design: Cross sectional study. Place and Duration of Study: Neonatal intensive care unit, department of pediatrics, Liaquat College of medicine a...

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Autores principales:	Erum Saboohi, Farhan Saeed, Rashid Naseem Khan, Muhammad Athar khan, Syed Adnan Ali, Aisha .
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	c-reactive protein early onset neonatal sepsis preterm septic screen term Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ccda8f2bbe48402d9849cada23a5029b
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spelling	oai:doaj.org-article:ccda8f2bbe48402d9849cada23a5029b2021-12-02T14:57:32ZC-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE0030-96482411-8842https://doaj.org/article/ccda8f2bbe48402d9849cada23a5029b2020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5862https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine C-reactive protein kinetics in term and preterm babies with early onset sepsis and its association with blood culture. Study Design: Cross sectional study. Place and Duration of Study: Neonatal intensive care unit, department of pediatrics, Liaquat College of medicine and dentistry and Darulsehat hospital Karachi, from Jan 2017 to Jan 2018. Methodology: One Hundred and Two neonates with presumed early onset sepsis (within 72 hours of birth) were enrolled in the study. Blood samples drawn for septic work up including baseline C-reactive protein levels. Blood culture collected with all recommended a-septic measures and is taken as gold standard for proven sepsis diagnosis. C-reactive protein considered positive when >6 mg/dl in preterm and >10mg/dl in term babies. Results: Out of 102 enrolled neonates, among C-reactive protein positive cases, 42.1% aged <24 hours, 50% were male, 47.5% had low birth weight, 63.2% were term, 36.8% preterm, 42% had positive blood culture, 5.3% observed with less than five thousand WBC, and 44.7% observed with more than twenty-five thousand WBC. Among these parame-ters blood culture and WBC >25000 gives significant association with C-reactive protein (p<0.01). Conclusion: Despite being septic, premature and low birth weight babies are unable to mount significant Creactive protein levels/C-reactive protein levels in these neonates do not effectively correlate with infectivity. Our study showed strong association of baseline C-reactive protein with WBC >25000/cumm and blood culture in term babies whose birth weights were appropriate for gestational age. To conclude, prematurity and low birth weight have negative association with C-reactive protein positivity hence in addition to clinical signs and risk factors, other sepsis screen parameters like interleukin, procalciton in should be taken into consideration before decision of antibiotic discontinuation in these neonates with presumed EOS. Erum SaboohiFarhan SaeedRashid Naseem KhanMuhammad Athar khanSyed Adnan AliAisha .Army Medical College Rawalpindiarticlec-reactive proteinearly onset neonatal sepsispretermseptic screentermMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1634-1639 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	c-reactive protein early onset neonatal sepsis preterm septic screen term Medicine R Medicine (General) R5-920
spellingShingle	c-reactive protein early onset neonatal sepsis preterm septic screen term Medicine R Medicine (General) R5-920 Erum Saboohi Farhan Saeed Rashid Naseem Khan Muhammad Athar khan Syed Adnan Ali Aisha . C-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE
description	Objective: To determine C-reactive protein kinetics in term and preterm babies with early onset sepsis and its association with blood culture. Study Design: Cross sectional study. Place and Duration of Study: Neonatal intensive care unit, department of pediatrics, Liaquat College of medicine and dentistry and Darulsehat hospital Karachi, from Jan 2017 to Jan 2018. Methodology: One Hundred and Two neonates with presumed early onset sepsis (within 72 hours of birth) were enrolled in the study. Blood samples drawn for septic work up including baseline C-reactive protein levels. Blood culture collected with all recommended a-septic measures and is taken as gold standard for proven sepsis diagnosis. C-reactive protein considered positive when >6 mg/dl in preterm and >10mg/dl in term babies. Results: Out of 102 enrolled neonates, among C-reactive protein positive cases, 42.1% aged <24 hours, 50% were male, 47.5% had low birth weight, 63.2% were term, 36.8% preterm, 42% had positive blood culture, 5.3% observed with less than five thousand WBC, and 44.7% observed with more than twenty-five thousand WBC. Among these parame-ters blood culture and WBC >25000 gives significant association with C-reactive protein (p<0.01). Conclusion: Despite being septic, premature and low birth weight babies are unable to mount significant Creactive protein levels/C-reactive protein levels in these neonates do not effectively correlate with infectivity. Our study showed strong association of baseline C-reactive protein with WBC >25000/cumm and blood culture in term babies whose birth weights were appropriate for gestational age. To conclude, prematurity and low birth weight have negative association with C-reactive protein positivity hence in addition to clinical signs and risk factors, other sepsis screen parameters like interleukin, procalciton in should be taken into consideration before decision of antibiotic discontinuation in these neonates with presumed EOS.
format	article
author	Erum Saboohi Farhan Saeed Rashid Naseem Khan Muhammad Athar khan Syed Adnan Ali Aisha .
author_facet	Erum Saboohi Farhan Saeed Rashid Naseem Khan Muhammad Athar khan Syed Adnan Ali Aisha .
author_sort	Erum Saboohi
title	C-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE
title_short	C-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE
title_full	C-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE
title_fullStr	C-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE
title_full_unstemmed	C-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE
title_sort	c-reactive protein kinetics in term and preterm babies with early onset sepsis and its association with blood culture
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/ccda8f2bbe48402d9849cada23a5029b
work_keys_str_mv	AT erumsaboohi creactiveproteinkineticsintermandpretermbabieswithearlyonsetsepsisanditsassociationwithbloodculture AT farhansaeed creactiveproteinkineticsintermandpretermbabieswithearlyonsetsepsisanditsassociationwithbloodculture AT rashidnaseemkhan creactiveproteinkineticsintermandpretermbabieswithearlyonsetsepsisanditsassociationwithbloodculture AT muhammadatharkhan creactiveproteinkineticsintermandpretermbabieswithearlyonsetsepsisanditsassociationwithbloodculture AT syedadnanali creactiveproteinkineticsintermandpretermbabieswithearlyonsetsepsisanditsassociationwithbloodculture AT aisha creactiveproteinkineticsintermandpretermbabieswithearlyonsetsepsisanditsassociationwithbloodculture
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C-REACTIVE PROTEIN KINETICS IN TERM AND PRETERM BABIES WITH EARLY ONSET SEPSIS AND ITS ASSOCIATION WITH BLOOD CULTURE

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