Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

While Sec61 enables ER import of all polypeptides with N-terminal signal peptides, only selected clients are accepted for TRAP-assisted ER import. Here, the authors use a proteomics approach to characterize TRAP-dependent clients, identifying signal peptide features that govern recognition by TRAP.

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Autores principales:	Duy Nguyen, Regine Stutz, Stefan Schorr, Sven Lang, Stefan Pfeffer, Hudson H. Freeze, Friedrich Förster, Volkhard Helms, Johanna Dudek, Richard Zimmermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccdad44d8b644ceabe5c045b8a8b8350
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spelling	oai:doaj.org-article:ccdad44d8b644ceabe5c045b8a8b83502021-12-02T14:38:52ZProteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import10.1038/s41467-018-06188-z2041-1723https://doaj.org/article/ccdad44d8b644ceabe5c045b8a8b83502018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06188-zhttps://doaj.org/toc/2041-1723While Sec61 enables ER import of all polypeptides with N-terminal signal peptides, only selected clients are accepted for TRAP-assisted ER import. Here, the authors use a proteomics approach to characterize TRAP-dependent clients, identifying signal peptide features that govern recognition by TRAP.Duy NguyenRegine StutzStefan SchorrSven LangStefan PfefferHudson H. FreezeFriedrich FörsterVolkhard HelmsJohanna DudekRichard ZimmermannNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Duy Nguyen Regine Stutz Stefan Schorr Sven Lang Stefan Pfeffer Hudson H. Freeze Friedrich Förster Volkhard Helms Johanna Dudek Richard Zimmermann Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
description	While Sec61 enables ER import of all polypeptides with N-terminal signal peptides, only selected clients are accepted for TRAP-assisted ER import. Here, the authors use a proteomics approach to characterize TRAP-dependent clients, identifying signal peptide features that govern recognition by TRAP.
format	article
author	Duy Nguyen Regine Stutz Stefan Schorr Sven Lang Stefan Pfeffer Hudson H. Freeze Friedrich Förster Volkhard Helms Johanna Dudek Richard Zimmermann
author_facet	Duy Nguyen Regine Stutz Stefan Schorr Sven Lang Stefan Pfeffer Hudson H. Freeze Friedrich Förster Volkhard Helms Johanna Dudek Richard Zimmermann
author_sort	Duy Nguyen
title	Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
title_short	Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
title_full	Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
title_fullStr	Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
title_full_unstemmed	Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import
title_sort	proteomics reveals signal peptide features determining the client specificity in human trap-dependent er protein import
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ccdad44d8b644ceabe5c045b8a8b8350
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Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

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