Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

While Sec61 enables ER import of all polypeptides with N-terminal signal peptides, only selected clients are accepted for TRAP-assisted ER import. Here, the authors use a proteomics approach to characterize TRAP-dependent clients, identifying signal peptide features that govern recognition by TRAP.

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Detalles Bibliográficos
Autores principales: Duy Nguyen, Regine Stutz, Stefan Schorr, Sven Lang, Stefan Pfeffer, Hudson H. Freeze, Friedrich Förster, Volkhard Helms, Johanna Dudek, Richard Zimmermann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/ccdad44d8b644ceabe5c045b8a8b8350
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