Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models

Hsiao-Chi Chuang,1,2,* Ta-Chih Hsiao,3,* Cheng-Kuan Wu,4 Hui-Hsien Chang,5 Chii-Hong Lee,6 Chih-Cheng Chang,1,2 Tsun-Jen Cheng4,7 On behalf of the Taiwan CardioPulmonary Research Group (T-CPR) 1School of Respiratory Therapy, College of Medicine, 2Division of Pulmonary Medicine, Department of Interna...

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Autores principales:	Chuang HC, Hsiao TC, Wu CK, Chang HH, Lee CH, Chang CC, Cheng TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cce147f4f30c43d9b329020fad3a3cc7
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spelling	oai:doaj.org-article:cce147f4f30c43d9b329020fad3a3cc72021-12-02T07:14:14ZAllergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models1176-91141178-2013https://doaj.org/article/cce147f4f30c43d9b329020fad3a3cc72013-11-01T00:00:00Zhttp://www.dovepress.com/allergenicity-and-toxicology-of-inhaled-silver-nanoparticles-in-allerg-a15054https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Hsiao-Chi Chuang,1,2,* Ta-Chih Hsiao,3,* Cheng-Kuan Wu,4 Hui-Hsien Chang,5 Chii-Hong Lee,6 Chih-Cheng Chang,1,2 Tsun-Jen Cheng4,7 On behalf of the Taiwan CardioPulmonary Research Group (T-CPR) 1School of Respiratory Therapy, College of Medicine, 2Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, 3Graduate Institute of Environmental Engineering, National Central University, Taoyuan, 4Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, 5Institute of Environmental Health, College of Public Health, National Taiwan University, 6Department of Pathology, Shuang Ho Hospital, Taipei Medical University, Taipei, 7Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan *These authors contributed equally to this work Abstract: Silver nanoparticles (AgNP) have been associated with the exacerbation of airway hyperresponsiveness. However, the allergenicity and toxicology of AgNP in healthy and allergic individuals are unclear. We investigated the pathophysiological responses to AgNP inhalation in a murine model of asthma. Continuous and stable levels of 33 nm AgNP were maintained at 3.3 mg/m3 during the experimental period. AgNP exposure concomitant with ovalbumin challenge increased the enhanced pause (Penh) in the control and allergic groups. AgNP evoked neutrophil, lymphocyte and eosinophil infiltration into the airways and elevated the levels of allergic markers (immunoglobulin E [IgE] and leukotriene E4 [LTE4]), the type 2 T helper (Th2) cytokine interleukin-13 (IL-13), and oxidative stress (8-hydroxy-2′-deoxyguanosine [8-OHdG]) in healthy and allergic mice. Bronchocentric interstitial inflammation was observed after AgNP inhalation. After inhalation, the AgNP accumulated predominantly in the lungs, and trivial amounts of AgNP were excreted in the urine and feces. Furthermore, the AgNP induced inflammatory responses in the peritoneum. The inhalation of AgNP may present safety concerns in healthy and susceptible individuals. Keywords: inductively coupled plasma-mass spectrometry, inflammation, leukotriene E4, ovalbumin, oxidative stressChuang HCHsiao TCWu CKChang HHLee CHChang CCCheng TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4495-4506 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chuang HC Hsiao TC Wu CK Chang HH Lee CH Chang CC Cheng TJ Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models
description	Hsiao-Chi Chuang,1,2,* Ta-Chih Hsiao,3,* Cheng-Kuan Wu,4 Hui-Hsien Chang,5 Chii-Hong Lee,6 Chih-Cheng Chang,1,2 Tsun-Jen Cheng4,7 On behalf of the Taiwan CardioPulmonary Research Group (T-CPR) 1School of Respiratory Therapy, College of Medicine, 2Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, 3Graduate Institute of Environmental Engineering, National Central University, Taoyuan, 4Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, 5Institute of Environmental Health, College of Public Health, National Taiwan University, 6Department of Pathology, Shuang Ho Hospital, Taipei Medical University, Taipei, 7Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan *These authors contributed equally to this work Abstract: Silver nanoparticles (AgNP) have been associated with the exacerbation of airway hyperresponsiveness. However, the allergenicity and toxicology of AgNP in healthy and allergic individuals are unclear. We investigated the pathophysiological responses to AgNP inhalation in a murine model of asthma. Continuous and stable levels of 33 nm AgNP were maintained at 3.3 mg/m3 during the experimental period. AgNP exposure concomitant with ovalbumin challenge increased the enhanced pause (Penh) in the control and allergic groups. AgNP evoked neutrophil, lymphocyte and eosinophil infiltration into the airways and elevated the levels of allergic markers (immunoglobulin E [IgE] and leukotriene E4 [LTE4]), the type 2 T helper (Th2) cytokine interleukin-13 (IL-13), and oxidative stress (8-hydroxy-2′-deoxyguanosine [8-OHdG]) in healthy and allergic mice. Bronchocentric interstitial inflammation was observed after AgNP inhalation. After inhalation, the AgNP accumulated predominantly in the lungs, and trivial amounts of AgNP were excreted in the urine and feces. Furthermore, the AgNP induced inflammatory responses in the peritoneum. The inhalation of AgNP may present safety concerns in healthy and susceptible individuals. Keywords: inductively coupled plasma-mass spectrometry, inflammation, leukotriene E4, ovalbumin, oxidative stress
format	article
author	Chuang HC Hsiao TC Wu CK Chang HH Lee CH Chang CC Cheng TJ
author_facet	Chuang HC Hsiao TC Wu CK Chang HH Lee CH Chang CC Cheng TJ
author_sort	Chuang HC
title	Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models
title_short	Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models
title_full	Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models
title_fullStr	Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models
title_full_unstemmed	Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models
title_sort	allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/cce147f4f30c43d9b329020fad3a3cc7
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Allergenicity and toxicology of inhaled silver nanoparticles in allergen-provocation mice models

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