Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease
Abstract Nonalcoholic fatty liver disease (NAFLD) is related to subclinical atherosclerosis. However, whether the severity of the disease (or which histopathological component) is associated with subclinical atherosclerosis remains controversial. This study aimed to investigate the association betwe...
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Nature Portfolio
2021
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oai:doaj.org-article:cce14aab56cd4efc9e98f6b71059a6f92021-12-02T14:53:49ZLiver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease10.1038/s41598-021-95581-82045-2322https://doaj.org/article/cce14aab56cd4efc9e98f6b71059a6f92021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95581-8https://doaj.org/toc/2045-2322Abstract Nonalcoholic fatty liver disease (NAFLD) is related to subclinical atherosclerosis. However, whether the severity of the disease (or which histopathological component) is associated with subclinical atherosclerosis remains controversial. This study aimed to investigate the association between the histopathological severity of NAFLD and carotid intima-media thickness (CIMT) in Japanese patients with liver biopsy-proven NAFLD. Maximum-CIMT (max-CIMT) was measured as an index of carotid atherosclerosis in 195 biopsy-proven NAFLD patients. A significant association was observed between the severity of fibrosis (but not steatosis, inflammation, and ballooning) and max-CIMT. Older age, male gender, hypertension, and advanced fibrosis were independently linked to max-CIMT ≥ 1.2 mm. The prevalence of max-CIMT ≥ 1.2 mm was significantly higher in the advanced fibrosis group than in the non-advanced fibrosis group (75.4% versus 44.0%; p < 0.01). Non-invasive liver fibrosis markers and scoring systems, including fibrosis-4 index, NAFLD fibrosis score, hyaluronic acid, and Wisteria floribunda agglutinin positive Mac-2-binding protein, demonstrated that the diagnostic performance for max-CIMT ≥ 1.2 mm was similar to that of biopsy-based fibrosis staging. In conclusion, advanced fibrosis is significantly and independently associated with high-risk CIMT. Non-invasive fibrosis markers and scoring systems could help estimate the risk of atherosclerosis progression in patients with NAFLD.Taeang AraiMasanori AtsukawaAkihito TsubotaKeizo KatoHiroshi AbeHirotaka OnoTadamichi KawanoYuji YoshidaTomohide TanabeTomomi OkuboKorenobu HayamaAi Nakagawa-IwashitaNorio ItokawaChisa KondoKeiko KanekoNaoya EmotoMototsugu NagaoKyoko InagakiIzumi FukudaHitoshi SugiharaKatsuhiko IwakiriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Taeang Arai Masanori Atsukawa Akihito Tsubota Keizo Kato Hiroshi Abe Hirotaka Ono Tadamichi Kawano Yuji Yoshida Tomohide Tanabe Tomomi Okubo Korenobu Hayama Ai Nakagawa-Iwashita Norio Itokawa Chisa Kondo Keiko Kaneko Naoya Emoto Mototsugu Nagao Kyoko Inagaki Izumi Fukuda Hitoshi Sugihara Katsuhiko Iwakiri Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease |
| description |
Abstract Nonalcoholic fatty liver disease (NAFLD) is related to subclinical atherosclerosis. However, whether the severity of the disease (or which histopathological component) is associated with subclinical atherosclerosis remains controversial. This study aimed to investigate the association between the histopathological severity of NAFLD and carotid intima-media thickness (CIMT) in Japanese patients with liver biopsy-proven NAFLD. Maximum-CIMT (max-CIMT) was measured as an index of carotid atherosclerosis in 195 biopsy-proven NAFLD patients. A significant association was observed between the severity of fibrosis (but not steatosis, inflammation, and ballooning) and max-CIMT. Older age, male gender, hypertension, and advanced fibrosis were independently linked to max-CIMT ≥ 1.2 mm. The prevalence of max-CIMT ≥ 1.2 mm was significantly higher in the advanced fibrosis group than in the non-advanced fibrosis group (75.4% versus 44.0%; p < 0.01). Non-invasive liver fibrosis markers and scoring systems, including fibrosis-4 index, NAFLD fibrosis score, hyaluronic acid, and Wisteria floribunda agglutinin positive Mac-2-binding protein, demonstrated that the diagnostic performance for max-CIMT ≥ 1.2 mm was similar to that of biopsy-based fibrosis staging. In conclusion, advanced fibrosis is significantly and independently associated with high-risk CIMT. Non-invasive fibrosis markers and scoring systems could help estimate the risk of atherosclerosis progression in patients with NAFLD. |
| format |
article |
| author |
Taeang Arai Masanori Atsukawa Akihito Tsubota Keizo Kato Hiroshi Abe Hirotaka Ono Tadamichi Kawano Yuji Yoshida Tomohide Tanabe Tomomi Okubo Korenobu Hayama Ai Nakagawa-Iwashita Norio Itokawa Chisa Kondo Keiko Kaneko Naoya Emoto Mototsugu Nagao Kyoko Inagaki Izumi Fukuda Hitoshi Sugihara Katsuhiko Iwakiri |
| author_facet |
Taeang Arai Masanori Atsukawa Akihito Tsubota Keizo Kato Hiroshi Abe Hirotaka Ono Tadamichi Kawano Yuji Yoshida Tomohide Tanabe Tomomi Okubo Korenobu Hayama Ai Nakagawa-Iwashita Norio Itokawa Chisa Kondo Keiko Kaneko Naoya Emoto Mototsugu Nagao Kyoko Inagaki Izumi Fukuda Hitoshi Sugihara Katsuhiko Iwakiri |
| author_sort |
Taeang Arai |
| title |
Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease |
| title_short |
Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease |
| title_full |
Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease |
| title_fullStr |
Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease |
| title_full_unstemmed |
Liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease |
| title_sort |
liver fibrosis is associated with carotid atherosclerosis in patients with liver biopsy-proven nonalcoholic fatty liver disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/cce14aab56cd4efc9e98f6b71059a6f9 |
| work_keys_str_mv |
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