Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults

Abstract Age affects the clinical outcomes of cancer treatment, including those for bone sarcoma. Successful reconstruction using frozen autograft after excision of bone sarcoma has been reported; however, little is known about the clinical outcomes of frozen autograft reconstruction according to ag...

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Autores principales:	Yoshihiro Araki, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano, Hiroyuki Tsuchiya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cce29096888e4185a2c69f8fb3e8ba64
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spelling	oai:doaj.org-article:cce29096888e4185a2c69f8fb3e8ba642021-12-02T16:34:58ZClinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults10.1038/s41598-021-96162-52045-2322https://doaj.org/article/cce29096888e4185a2c69f8fb3e8ba642021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96162-5https://doaj.org/toc/2045-2322Abstract Age affects the clinical outcomes of cancer treatment, including those for bone sarcoma. Successful reconstruction using frozen autograft after excision of bone sarcoma has been reported; however, little is known about the clinical outcomes of frozen autograft reconstruction according to age. The purpose was to evaluate the clinical outcomes of the frozen autograft reconstruction focusing on skeletally mature adolescents and young adults (AYAs) that was 15 to 39 years of age. A total of 37 AYA patients with primary bone sarcoma on the appendicular skeleton were enrolled in this study. The mean follow-up period was 89 months. The graft survival (GS), overall survival (OS), recurrence-free survival (RFS), complications and the function were retrospectively evaluated using medical records. The 10-year GS, OS, and RFS rates were 76%, 84%, and 79%, respectively. Bone union was achieved with a rate of 94% within 1 year after surgery, and nonunion (n = 1) and fracture (n = 2) were infrequently observed. Graft removal was performed in 7 cases, and the most common reason for the removal was infection (n = 5). The Musculoskeletal Tumor Society score was excellent in 23 cases of the available 29 cases. Frozen autograft reconstruction for AYAs showed excellent clinical outcomes, although the long-term follow-up is required.Yoshihiro ArakiNorio YamamotoKatsuhiro HayashiAkihiko TakeuchiShinji MiwaKentaro IgarashiTakashi HiguchiKensaku AbeYuta TaniguchiHirotaka YonezawaSei MorinagaYohei AsanoHiroyuki TsuchiyaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshihiro Araki Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Takashi Higuchi Kensaku Abe Yuta Taniguchi Hirotaka Yonezawa Sei Morinaga Yohei Asano Hiroyuki Tsuchiya Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults
description	Abstract Age affects the clinical outcomes of cancer treatment, including those for bone sarcoma. Successful reconstruction using frozen autograft after excision of bone sarcoma has been reported; however, little is known about the clinical outcomes of frozen autograft reconstruction according to age. The purpose was to evaluate the clinical outcomes of the frozen autograft reconstruction focusing on skeletally mature adolescents and young adults (AYAs) that was 15 to 39 years of age. A total of 37 AYA patients with primary bone sarcoma on the appendicular skeleton were enrolled in this study. The mean follow-up period was 89 months. The graft survival (GS), overall survival (OS), recurrence-free survival (RFS), complications and the function were retrospectively evaluated using medical records. The 10-year GS, OS, and RFS rates were 76%, 84%, and 79%, respectively. Bone union was achieved with a rate of 94% within 1 year after surgery, and nonunion (n = 1) and fracture (n = 2) were infrequently observed. Graft removal was performed in 7 cases, and the most common reason for the removal was infection (n = 5). The Musculoskeletal Tumor Society score was excellent in 23 cases of the available 29 cases. Frozen autograft reconstruction for AYAs showed excellent clinical outcomes, although the long-term follow-up is required.
format	article
author	Yoshihiro Araki Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Takashi Higuchi Kensaku Abe Yuta Taniguchi Hirotaka Yonezawa Sei Morinaga Yohei Asano Hiroyuki Tsuchiya
author_facet	Yoshihiro Araki Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Takashi Higuchi Kensaku Abe Yuta Taniguchi Hirotaka Yonezawa Sei Morinaga Yohei Asano Hiroyuki Tsuchiya
author_sort	Yoshihiro Araki
title	Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults
title_short	Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults
title_full	Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults
title_fullStr	Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults
title_full_unstemmed	Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults
title_sort	clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cce29096888e4185a2c69f8fb3e8ba64
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Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults

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