Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models

Feingold syndrome is a skeletal dysplasia caused by mutations in MYCN or MIR17HG, but it is not clear if these mutations lead to pathology via a common molecular mechanism. Here, the authors show that mutations in MIR17HG lead to upregulated TGF-β signaling in limb mesenchymal cells, while mutations...

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Autores principales:	Fatemeh Mirzamohammadi, Anastasia Kozlova, Garyfallia Papaioannou, Elena Paltrinieri, Ugur M. Ayturk, Tatsuya Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cce31e82791243b5bd7fb58a95b1fffa
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spelling	oai:doaj.org-article:cce31e82791243b5bd7fb58a95b1fffa2021-12-02T15:34:26ZDistinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models10.1038/s41467-018-03788-72041-1723https://doaj.org/article/cce31e82791243b5bd7fb58a95b1fffa2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03788-7https://doaj.org/toc/2041-1723Feingold syndrome is a skeletal dysplasia caused by mutations in MYCN or MIR17HG, but it is not clear if these mutations lead to pathology via a common molecular mechanism. Here, the authors show that mutations in MIR17HG lead to upregulated TGF-β signaling in limb mesenchymal cells, while mutations in MYCN downregulate PI3K signaling.Fatemeh MirzamohammadiAnastasia KozlovaGaryfallia PapaioannouElena PaltrinieriUgur M. AyturkTatsuya KobayashiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fatemeh Mirzamohammadi Anastasia Kozlova Garyfallia Papaioannou Elena Paltrinieri Ugur M. Ayturk Tatsuya Kobayashi Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models
description	Feingold syndrome is a skeletal dysplasia caused by mutations in MYCN or MIR17HG, but it is not clear if these mutations lead to pathology via a common molecular mechanism. Here, the authors show that mutations in MIR17HG lead to upregulated TGF-β signaling in limb mesenchymal cells, while mutations in MYCN downregulate PI3K signaling.
format	article
author	Fatemeh Mirzamohammadi Anastasia Kozlova Garyfallia Papaioannou Elena Paltrinieri Ugur M. Ayturk Tatsuya Kobayashi
author_facet	Fatemeh Mirzamohammadi Anastasia Kozlova Garyfallia Papaioannou Elena Paltrinieri Ugur M. Ayturk Tatsuya Kobayashi
author_sort	Fatemeh Mirzamohammadi
title	Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models
title_short	Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models
title_full	Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models
title_fullStr	Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models
title_full_unstemmed	Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models
title_sort	distinct molecular pathways mediate mycn and myc-regulated mir-17-92 microrna action in feingold syndrome mouse models
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cce31e82791243b5bd7fb58a95b1fffa
work_keys_str_mv	AT fatemehmirzamohammadi distinctmolecularpathwaysmediatemycnandmycregulatedmir1792micrornaactioninfeingoldsyndromemousemodels AT anastasiakozlova distinctmolecularpathwaysmediatemycnandmycregulatedmir1792micrornaactioninfeingoldsyndromemousemodels AT garyfalliapapaioannou distinctmolecularpathwaysmediatemycnandmycregulatedmir1792micrornaactioninfeingoldsyndromemousemodels AT elenapaltrinieri distinctmolecularpathwaysmediatemycnandmycregulatedmir1792micrornaactioninfeingoldsyndromemousemodels AT ugurmayturk distinctmolecularpathwaysmediatemycnandmycregulatedmir1792micrornaactioninfeingoldsyndromemousemodels AT tatsuyakobayashi distinctmolecularpathwaysmediatemycnandmycregulatedmir1792micrornaactioninfeingoldsyndromemousemodels
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Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models

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