Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid

Abstract Hepatocellular carcinoma (HCC) treatment remains lack of effective chemopreventive agents, therefore it is very attractive and urgent to discover novel anti-HCC drugs. In the present study, the effects of chlorogenic acid (ChA) and caffeic acid (CaA) on HCC induced by diethylnitrosamine (DE...

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Autores principales:	Zhan Zhang, Di Wang, Shanlei Qiao, Xinyue Wu, Shuyuan Cao, Li Wang, Xiaojian Su, Lei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cce35029c8e040e9ac0b92902dd2de46
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spelling	oai:doaj.org-article:cce35029c8e040e9ac0b92902dd2de462021-12-02T11:53:07ZMetabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid10.1038/s41598-017-04888-y2045-2322https://doaj.org/article/cce35029c8e040e9ac0b92902dd2de462017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04888-yhttps://doaj.org/toc/2045-2322Abstract Hepatocellular carcinoma (HCC) treatment remains lack of effective chemopreventive agents, therefore it is very attractive and urgent to discover novel anti-HCC drugs. In the present study, the effects of chlorogenic acid (ChA) and caffeic acid (CaA) on HCC induced by diethylnitrosamine (DEN) were evaluated. ChA or CaA could reduce the histopathological changes and liver injury markers, such as alanine transarninase, aspartate aminotransferase, alkaline phosphatase, total bile acid, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol. The underlying mechanisms were investigated by a data integration strategy based on correlation analyses of metabonomics data and 16 S rRNA gene sequencing data. ChA or CaA could inhibit the increase of Rumincoccaceae UCG-004 and reduction of Lachnospiraceae incertae sedis, and Prevotella 9 in HCC rats. The principal component analysis and partial least squares discriminant analysis were applied to reveal the metabolic differences among these groups. 28 different metabolites showed a trend to return to normal in both CaA and ChA treatment. Among them, Bilirubin, L-Tyrosine, L-Methionine and Ethanolamine were correlated increased Rumincoccaceae UCG-004 and decreased of Lachnospiraceae incertae sedis and Prevotella 9. These correlations could be identified as metabolic and microbial signatures of HCC onset and potential therapeutic targets.Zhan ZhangDi WangShanlei QiaoXinyue WuShuyuan CaoLi WangXiaojian SuLei LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhan Zhang Di Wang Shanlei Qiao Xinyue Wu Shuyuan Cao Li Wang Xiaojian Su Lei Li Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid
description	Abstract Hepatocellular carcinoma (HCC) treatment remains lack of effective chemopreventive agents, therefore it is very attractive and urgent to discover novel anti-HCC drugs. In the present study, the effects of chlorogenic acid (ChA) and caffeic acid (CaA) on HCC induced by diethylnitrosamine (DEN) were evaluated. ChA or CaA could reduce the histopathological changes and liver injury markers, such as alanine transarninase, aspartate aminotransferase, alkaline phosphatase, total bile acid, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol. The underlying mechanisms were investigated by a data integration strategy based on correlation analyses of metabonomics data and 16 S rRNA gene sequencing data. ChA or CaA could inhibit the increase of Rumincoccaceae UCG-004 and reduction of Lachnospiraceae incertae sedis, and Prevotella 9 in HCC rats. The principal component analysis and partial least squares discriminant analysis were applied to reveal the metabolic differences among these groups. 28 different metabolites showed a trend to return to normal in both CaA and ChA treatment. Among them, Bilirubin, L-Tyrosine, L-Methionine and Ethanolamine were correlated increased Rumincoccaceae UCG-004 and decreased of Lachnospiraceae incertae sedis and Prevotella 9. These correlations could be identified as metabolic and microbial signatures of HCC onset and potential therapeutic targets.
format	article
author	Zhan Zhang Di Wang Shanlei Qiao Xinyue Wu Shuyuan Cao Li Wang Xiaojian Su Lei Li
author_facet	Zhan Zhang Di Wang Shanlei Qiao Xinyue Wu Shuyuan Cao Li Wang Xiaojian Su Lei Li
author_sort	Zhan Zhang
title	Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid
title_short	Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid
title_full	Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid
title_fullStr	Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid
title_full_unstemmed	Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid
title_sort	metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cce35029c8e040e9ac0b92902dd2de46
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Metabolic and microbial signatures in rat hepatocellular carcinoma treated with caffeic acid and chlorogenic acid

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