Genome wide analysis of fertility and production traits in Italian Holstein cattle.

A genome wide scan was performed on a total of 2093 Italian Holstein proven bulls genotyped with 50K single nucleotide polymorphisms (SNPs), with the objective of identifying loci associated with fertility related traits and to test their effects on milk production traits. The analysis was carried o...

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Autores principales:	Giulietta Minozzi, Ezequiel L Nicolazzi, Alessandra Stella, Stefano Biffani, Riccardo Negrini, Barbara Lazzari, Paolo Ajmone-Marsan, John L Williams
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cce5034b0dff4e879584430eb88fd224
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spelling	oai:doaj.org-article:cce5034b0dff4e879584430eb88fd2242021-11-18T08:47:04ZGenome wide analysis of fertility and production traits in Italian Holstein cattle.1932-620310.1371/journal.pone.0080219https://doaj.org/article/cce5034b0dff4e879584430eb88fd2242013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265800/?tool=EBIhttps://doaj.org/toc/1932-6203A genome wide scan was performed on a total of 2093 Italian Holstein proven bulls genotyped with 50K single nucleotide polymorphisms (SNPs), with the objective of identifying loci associated with fertility related traits and to test their effects on milk production traits. The analysis was carried out using estimated breeding values for the aggregate fertility index and for each trait contributing to the index: angularity, calving interval, non-return rate at 56 days, days to first service, and 305 day first parity lactation. In addition, two production traits not included in the aggregate fertility index were analysed: fat yield and protein yield. Analyses were carried out using all SNPs treated separately, further the most significant marker on BTA14 associated to milk quality located in the DGAT1 region was treated as fixed effect. Genome wide association analysis identified 61 significant SNPs and 75 significant marker-trait associations. Eight additional SNP associations were detected when SNP located near DGAT1 was included as a fixed effect. As there were no obvious common SNPs between the traits analyzed independently in this study, a network analysis was carried out to identify unforeseen relationships that may link production and fertility traits.Giulietta MinozziEzequiel L NicolazziAlessandra StellaStefano BiffaniRiccardo NegriniBarbara LazzariPaolo Ajmone-MarsanJohn L WilliamsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80219 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giulietta Minozzi Ezequiel L Nicolazzi Alessandra Stella Stefano Biffani Riccardo Negrini Barbara Lazzari Paolo Ajmone-Marsan John L Williams Genome wide analysis of fertility and production traits in Italian Holstein cattle.
description	A genome wide scan was performed on a total of 2093 Italian Holstein proven bulls genotyped with 50K single nucleotide polymorphisms (SNPs), with the objective of identifying loci associated with fertility related traits and to test their effects on milk production traits. The analysis was carried out using estimated breeding values for the aggregate fertility index and for each trait contributing to the index: angularity, calving interval, non-return rate at 56 days, days to first service, and 305 day first parity lactation. In addition, two production traits not included in the aggregate fertility index were analysed: fat yield and protein yield. Analyses were carried out using all SNPs treated separately, further the most significant marker on BTA14 associated to milk quality located in the DGAT1 region was treated as fixed effect. Genome wide association analysis identified 61 significant SNPs and 75 significant marker-trait associations. Eight additional SNP associations were detected when SNP located near DGAT1 was included as a fixed effect. As there were no obvious common SNPs between the traits analyzed independently in this study, a network analysis was carried out to identify unforeseen relationships that may link production and fertility traits.
format	article
author	Giulietta Minozzi Ezequiel L Nicolazzi Alessandra Stella Stefano Biffani Riccardo Negrini Barbara Lazzari Paolo Ajmone-Marsan John L Williams
author_facet	Giulietta Minozzi Ezequiel L Nicolazzi Alessandra Stella Stefano Biffani Riccardo Negrini Barbara Lazzari Paolo Ajmone-Marsan John L Williams
author_sort	Giulietta Minozzi
title	Genome wide analysis of fertility and production traits in Italian Holstein cattle.
title_short	Genome wide analysis of fertility and production traits in Italian Holstein cattle.
title_full	Genome wide analysis of fertility and production traits in Italian Holstein cattle.
title_fullStr	Genome wide analysis of fertility and production traits in Italian Holstein cattle.
title_full_unstemmed	Genome wide analysis of fertility and production traits in Italian Holstein cattle.
title_sort	genome wide analysis of fertility and production traits in italian holstein cattle.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/cce5034b0dff4e879584430eb88fd224
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Genome wide analysis of fertility and production traits in Italian Holstein cattle.

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