Brain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study

Diminished physical growth is a common marker of malnutrition and it affects approximately 200 million children worldwide. Despite its importance and prevalence, it is not clear whether diminished growth relates to brain development and general cognitive ability. Further, diminished growth is more c...

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Autores principales:	Ted K. Turesky, Talat Shama, Shahria Hafiz Kakon, Rashidul Haque, Nazrul Islam, Amala Someshwar, Borjan Gagoski, William A. Petri, Jr., Charles A. Nelson, Nadine Gaab
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Adversity Brain Morphometry MRI Poverty Stunting Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/cce85db864044e43a66393254e05170f
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spelling	oai:doaj.org-article:cce85db864044e43a66393254e05170f2021-11-20T04:58:17ZBrain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study1878-929310.1016/j.dcn.2021.101029https://doaj.org/article/cce85db864044e43a66393254e05170f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878929321001183https://doaj.org/toc/1878-9293Diminished physical growth is a common marker of malnutrition and it affects approximately 200 million children worldwide. Despite its importance and prevalence, it is not clear whether diminished growth relates to brain development and general cognitive ability. Further, diminished growth is more common in areas of extreme poverty, raising the possibility that it may mediate previously shown links between socioeconomic status (SES) and brain structure. To address these gaps, 79 children growing up in an extremely poor, urban area of Bangladesh underwent MRI at age six years. Structural brain images were submitted to Mindboggle software, a Docker-compliant and high-reproducibility tool for tissue segmentation and regional estimations of volume, surface area, cortical thickness, sulcal depth, and mean curvature. Diminished growth predicted brain morphometry and mediated the link between SES and brain morphometry most consistently for subcortical and white matter subcortical volumes. Meanwhile, brain volume in left pallidum and right ventral diencephalon mediated the relationship between diminished growth and full-scale IQ. These findings offer malnutrition as one possible pathway through which SES affects brain development and general cognitive ability in areas of extreme poverty.Ted K. TureskyTalat ShamaShahria Hafiz KakonRashidul HaqueNazrul IslamAmala SomeshwarBorjan GagoskiWilliam A. Petri, Jr.Charles A. NelsonNadine GaabElsevierarticleAdversityBrainMorphometryMRIPovertyStuntingNeurophysiology and neuropsychologyQP351-495ENDevelopmental Cognitive Neuroscience, Vol 52, Iss , Pp 101029- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adversity Brain Morphometry MRI Poverty Stunting Neurophysiology and neuropsychology QP351-495
spellingShingle	Adversity Brain Morphometry MRI Poverty Stunting Neurophysiology and neuropsychology QP351-495 Ted K. Turesky Talat Shama Shahria Hafiz Kakon Rashidul Haque Nazrul Islam Amala Someshwar Borjan Gagoski William A. Petri, Jr. Charles A. Nelson Nadine Gaab Brain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study
description	Diminished physical growth is a common marker of malnutrition and it affects approximately 200 million children worldwide. Despite its importance and prevalence, it is not clear whether diminished growth relates to brain development and general cognitive ability. Further, diminished growth is more common in areas of extreme poverty, raising the possibility that it may mediate previously shown links between socioeconomic status (SES) and brain structure. To address these gaps, 79 children growing up in an extremely poor, urban area of Bangladesh underwent MRI at age six years. Structural brain images were submitted to Mindboggle software, a Docker-compliant and high-reproducibility tool for tissue segmentation and regional estimations of volume, surface area, cortical thickness, sulcal depth, and mean curvature. Diminished growth predicted brain morphometry and mediated the link between SES and brain morphometry most consistently for subcortical and white matter subcortical volumes. Meanwhile, brain volume in left pallidum and right ventral diencephalon mediated the relationship between diminished growth and full-scale IQ. These findings offer malnutrition as one possible pathway through which SES affects brain development and general cognitive ability in areas of extreme poverty.
format	article
author	Ted K. Turesky Talat Shama Shahria Hafiz Kakon Rashidul Haque Nazrul Islam Amala Someshwar Borjan Gagoski William A. Petri, Jr. Charles A. Nelson Nadine Gaab
author_facet	Ted K. Turesky Talat Shama Shahria Hafiz Kakon Rashidul Haque Nazrul Islam Amala Someshwar Borjan Gagoski William A. Petri, Jr. Charles A. Nelson Nadine Gaab
author_sort	Ted K. Turesky
title	Brain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study
title_short	Brain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study
title_full	Brain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study
title_fullStr	Brain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study
title_full_unstemmed	Brain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study
title_sort	brain morphometry and diminished physical growth in bangladeshi children growing up in extreme poverty: a longitudinal study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cce85db864044e43a66393254e05170f
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Brain morphometry and diminished physical growth in Bangladeshi children growing up in extreme poverty: A longitudinal study

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