The genomic landscape of tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem tumour growth. Here the authors analyse 111 TSC-associated tissues for TSC1/TSC2 status, DNA mutations, copy number aberrations, differential gene expression and DNA methylation patterns providing a comprehensive genomic...

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Autores principales:	Katie R. Martin, Wanding Zhou, Megan J. Bowman, Juliann Shih, Kit Sing Au, Kristin E. Dittenhafer-Reed, Kellie A. Sisson, Julie Koeman, Daniel J. Weisenberger, Sandra L. Cottingham, Steven T. DeRoos, Orrin Devinsky, Mary E. Winn, Andrew D. Cherniack, Hui Shen, Hope Northrup, Darcy A. Krueger, Jeffrey P. MacKeigan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cce878691c884b4cbf1df21c1d12c2c9
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spelling	oai:doaj.org-article:cce878691c884b4cbf1df21c1d12c2c92021-12-02T17:06:12ZThe genomic landscape of tuberous sclerosis complex10.1038/ncomms158162041-1723https://doaj.org/article/cce878691c884b4cbf1df21c1d12c2c92017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15816https://doaj.org/toc/2041-1723Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem tumour growth. Here the authors analyse 111 TSC-associated tissues for TSC1/TSC2 status, DNA mutations, copy number aberrations, differential gene expression and DNA methylation patterns providing a comprehensive genomic landscape.Katie R. MartinWanding ZhouMegan J. BowmanJuliann ShihKit Sing AuKristin E. Dittenhafer-ReedKellie A. SissonJulie KoemanDaniel J. WeisenbergerSandra L. CottinghamSteven T. DeRoosOrrin DevinskyMary E. WinnAndrew D. CherniackHui ShenHope NorthrupDarcy A. KruegerJeffrey P. MacKeiganNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katie R. Martin Wanding Zhou Megan J. Bowman Juliann Shih Kit Sing Au Kristin E. Dittenhafer-Reed Kellie A. Sisson Julie Koeman Daniel J. Weisenberger Sandra L. Cottingham Steven T. DeRoos Orrin Devinsky Mary E. Winn Andrew D. Cherniack Hui Shen Hope Northrup Darcy A. Krueger Jeffrey P. MacKeigan The genomic landscape of tuberous sclerosis complex
description	Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem tumour growth. Here the authors analyse 111 TSC-associated tissues for TSC1/TSC2 status, DNA mutations, copy number aberrations, differential gene expression and DNA methylation patterns providing a comprehensive genomic landscape.
format	article
author	Katie R. Martin Wanding Zhou Megan J. Bowman Juliann Shih Kit Sing Au Kristin E. Dittenhafer-Reed Kellie A. Sisson Julie Koeman Daniel J. Weisenberger Sandra L. Cottingham Steven T. DeRoos Orrin Devinsky Mary E. Winn Andrew D. Cherniack Hui Shen Hope Northrup Darcy A. Krueger Jeffrey P. MacKeigan
author_facet	Katie R. Martin Wanding Zhou Megan J. Bowman Juliann Shih Kit Sing Au Kristin E. Dittenhafer-Reed Kellie A. Sisson Julie Koeman Daniel J. Weisenberger Sandra L. Cottingham Steven T. DeRoos Orrin Devinsky Mary E. Winn Andrew D. Cherniack Hui Shen Hope Northrup Darcy A. Krueger Jeffrey P. MacKeigan
author_sort	Katie R. Martin
title	The genomic landscape of tuberous sclerosis complex
title_short	The genomic landscape of tuberous sclerosis complex
title_full	The genomic landscape of tuberous sclerosis complex
title_fullStr	The genomic landscape of tuberous sclerosis complex
title_full_unstemmed	The genomic landscape of tuberous sclerosis complex
title_sort	genomic landscape of tuberous sclerosis complex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cce878691c884b4cbf1df21c1d12c2c9
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The genomic landscape of tuberous sclerosis complex

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