Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.

This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg(9)-BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Herbert Gustavo Simões, Ricardo Yukio Asano, Marcelo Magalhães Sales, Rodrigo Alberto Vieira Browne, Gisela Arsa, Daisy Motta-Santos, Guilherme Morais Puga, Laila Cândida de Jesus Lima, Carmen Sílvia Grubert Campbell, Octavio Luiz Franco
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cced38825bc7417d9928673ac8ae3949
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cced38825bc7417d9928673ac8ae3949
record_format	dspace
spelling	oai:doaj.org-article:cced38825bc7417d9928673ac8ae39492021-11-18T08:47:02ZType 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.1932-620310.1371/journal.pone.0080348https://doaj.org/article/cced38825bc7417d9928673ac8ae39492013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24265812/?tool=EBIhttps://doaj.org/toc/1932-6203This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg(9)-BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 diabetes (T2D) and 10 without type 2 diabetes (ND) underwent three sessions: 1) maximal incremental test on cycle ergometer to determine lactate threshold (LT); 2) 20-min of constant-load exercise on cycle ergometer, at 90% LT and; 3) control session. BP and oxygen uptake were measured at rest and at 15, 30 and 45 min post-exercise. Venous blood samples were collected at 15 and 45 minutes of the recovery period for further analysis of PKA, BK and DesArg(9)-BK. Nitrite plus nitrate (NOx) was analyzed at 15 minutes post exercise. The ND group presented post-exercise hypotension (PEH) of systolic blood pressure and mean arterial pressure on the 90% LT session but T2D group did not. Plasma NOx increased ~24.4% for ND and ~13.8% for T2D group 15 min after the exercise session. Additionally, only ND individuals showed increases in PKA and BK in response to exercise and only T2D group showed increased DesArg(9)-BK production. It was concluded that T2D individuals presented lower PKA, BK and NOx release as well as higher DesArg(9)-BK production and reduced PEH in relation to ND participants after a single exercise session.Herbert Gustavo SimõesRicardo Yukio AsanoMarcelo Magalhães SalesRodrigo Alberto Vieira BrowneGisela ArsaDaisy Motta-SantosGuilherme Morais PugaLaila Cândida de Jesus LimaCarmen Sílvia Grubert CampbellOctavio Luiz FrancoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80348 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Herbert Gustavo Simões Ricardo Yukio Asano Marcelo Magalhães Sales Rodrigo Alberto Vieira Browne Gisela Arsa Daisy Motta-Santos Guilherme Morais Puga Laila Cândida de Jesus Lima Carmen Sílvia Grubert Campbell Octavio Luiz Franco Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.
description	This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg(9)-BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 diabetes (T2D) and 10 without type 2 diabetes (ND) underwent three sessions: 1) maximal incremental test on cycle ergometer to determine lactate threshold (LT); 2) 20-min of constant-load exercise on cycle ergometer, at 90% LT and; 3) control session. BP and oxygen uptake were measured at rest and at 15, 30 and 45 min post-exercise. Venous blood samples were collected at 15 and 45 minutes of the recovery period for further analysis of PKA, BK and DesArg(9)-BK. Nitrite plus nitrate (NOx) was analyzed at 15 minutes post exercise. The ND group presented post-exercise hypotension (PEH) of systolic blood pressure and mean arterial pressure on the 90% LT session but T2D group did not. Plasma NOx increased ~24.4% for ND and ~13.8% for T2D group 15 min after the exercise session. Additionally, only ND individuals showed increases in PKA and BK in response to exercise and only T2D group showed increased DesArg(9)-BK production. It was concluded that T2D individuals presented lower PKA, BK and NOx release as well as higher DesArg(9)-BK production and reduced PEH in relation to ND participants after a single exercise session.
format	article
author	Herbert Gustavo Simões Ricardo Yukio Asano Marcelo Magalhães Sales Rodrigo Alberto Vieira Browne Gisela Arsa Daisy Motta-Santos Guilherme Morais Puga Laila Cândida de Jesus Lima Carmen Sílvia Grubert Campbell Octavio Luiz Franco
author_facet	Herbert Gustavo Simões Ricardo Yukio Asano Marcelo Magalhães Sales Rodrigo Alberto Vieira Browne Gisela Arsa Daisy Motta-Santos Guilherme Morais Puga Laila Cândida de Jesus Lima Carmen Sílvia Grubert Campbell Octavio Luiz Franco
author_sort	Herbert Gustavo Simões
title	Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.
title_short	Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.
title_full	Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.
title_fullStr	Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.
title_full_unstemmed	Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.
title_sort	type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher desarg(9)-bk and reduced post-exercise hypotension compared to non-diabetic condition.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/cced38825bc7417d9928673ac8ae3949
work_keys_str_mv	AT herbertgustavosimoes type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT ricardoyukioasano type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT marcelomagalhaessales type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT rodrigoalbertovieirabrowne type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT giselaarsa type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT daisymottasantos type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT guilhermemoraispuga type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT lailacandidadejesuslima type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT carmensilviagrubertcampbell type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition AT octavioluizfranco type2diabeteselicitslowernitricoxidebradykininconcentrationandkallikreinactivitytogetherwithhigherdesarg9bkandreducedpostexercisehypotensioncomparedtonondiabeticcondition
_version_	1718421350195920896

Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition.

Ejemplares similares