Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.

Performance of timed motor sequences relies on the cerebellum and basal ganglia, which integrate proprioceptive information during the motor task and set internal timing mechanisms. Accordingly, these structures are also involved in other temporal processes, such as the discrimination of the differe...

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Autores principales:	Michele Tinazzi, Francesca Morgante, Alessia Peretti, Caterina Mariotti, Marta Panzeri, Mirta Fiorio, Alfonso Fasano
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ccefb159a96c42de97f5841ee9b273f9
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spelling	oai:doaj.org-article:ccefb159a96c42de97f5841ee9b273f92021-11-18T08:47:34ZImpaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.1932-620310.1371/journal.pone.0078628https://doaj.org/article/ccefb159a96c42de97f5841ee9b273f92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244328/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Performance of timed motor sequences relies on the cerebellum and basal ganglia, which integrate proprioceptive information during the motor task and set internal timing mechanisms. Accordingly, these structures are also involved in other temporal processes, such as the discrimination of the different afferent information in the domain of time. In the present study we tested temporal processing of proprioceptive and tactile stimuli in 20 patients with neurodegenerative cerebellar ataxia and 20 age- and sex-matched healthy subjects. Tactile temporal discrimination threshold was defined as the value at which subjects recognized the two stimuli as asynchronous. Temporal discrimination movement threshold of the first dorsal interosseous and flexor carpi radialis was defined as the shortest interval between two paired electrical stimuli in which the subjects blindfolded perceived two separate index finger abductions and wrist flexions. Both tactile and movement temporal discrimination thresholds were higher in patients with cerebellar ataxia. No correlation was found with disease duration and severity. Our study demonstrates that temporal processing of tactile and proprioceptive stimuli is impaired in patients with cerebellar neurodegeneration and highlights the involvement of cerebellum in temporal processing of somatosensory stimuli of different type.Michele TinazziFrancesca MorganteAlessia PerettiCaterina MariottiMarta PanzeriMirta FiorioAlfonso FasanoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e78628 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michele Tinazzi Francesca Morgante Alessia Peretti Caterina Mariotti Marta Panzeri Mirta Fiorio Alfonso Fasano Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.
description	Performance of timed motor sequences relies on the cerebellum and basal ganglia, which integrate proprioceptive information during the motor task and set internal timing mechanisms. Accordingly, these structures are also involved in other temporal processes, such as the discrimination of the different afferent information in the domain of time. In the present study we tested temporal processing of proprioceptive and tactile stimuli in 20 patients with neurodegenerative cerebellar ataxia and 20 age- and sex-matched healthy subjects. Tactile temporal discrimination threshold was defined as the value at which subjects recognized the two stimuli as asynchronous. Temporal discrimination movement threshold of the first dorsal interosseous and flexor carpi radialis was defined as the shortest interval between two paired electrical stimuli in which the subjects blindfolded perceived two separate index finger abductions and wrist flexions. Both tactile and movement temporal discrimination thresholds were higher in patients with cerebellar ataxia. No correlation was found with disease duration and severity. Our study demonstrates that temporal processing of tactile and proprioceptive stimuli is impaired in patients with cerebellar neurodegeneration and highlights the involvement of cerebellum in temporal processing of somatosensory stimuli of different type.
format	article
author	Michele Tinazzi Francesca Morgante Alessia Peretti Caterina Mariotti Marta Panzeri Mirta Fiorio Alfonso Fasano
author_facet	Michele Tinazzi Francesca Morgante Alessia Peretti Caterina Mariotti Marta Panzeri Mirta Fiorio Alfonso Fasano
author_sort	Michele Tinazzi
title	Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.
title_short	Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.
title_full	Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.
title_fullStr	Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.
title_full_unstemmed	Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.
title_sort	impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ccefb159a96c42de97f5841ee9b273f9
work_keys_str_mv	AT micheletinazzi impairedtemporalprocessingoftactileandproprioceptivestimuliincerebellardegeneration AT francescamorgante impairedtemporalprocessingoftactileandproprioceptivestimuliincerebellardegeneration AT alessiaperetti impairedtemporalprocessingoftactileandproprioceptivestimuliincerebellardegeneration AT caterinamariotti impairedtemporalprocessingoftactileandproprioceptivestimuliincerebellardegeneration AT martapanzeri impairedtemporalprocessingoftactileandproprioceptivestimuliincerebellardegeneration AT mirtafiorio impairedtemporalprocessingoftactileandproprioceptivestimuliincerebellardegeneration AT alfonsofasano impairedtemporalprocessingoftactileandproprioceptivestimuliincerebellardegeneration
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Impaired temporal processing of tactile and proprioceptive stimuli in cerebellar degeneration.

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