Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling

Bock et al. characterise the adaptation of Pseudomonas aeruginosa to the antiseptic octenidine, using whole genome sequencing, gene expression studies and metabolomics. They attribute this increased tolerance to synergistic changes in efflux and plasma membrane composition via mutations in SmvR, the...

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Autores principales:	Lucy J. Bock, Philip M. Ferguson, Maria Clarke, Vichayanee Pumpitakkul, Matthew E. Wand, Paul-Enguerrand Fady, Leanne Allison, Roland A. Fleck, Matthew J. Shepherd, A. James Mason, J. Mark Sutton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ccf2e3e15e54451f801b309bb3ca6810
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spelling	oai:doaj.org-article:ccf2e3e15e54451f801b309bb3ca68102021-12-02T17:19:12ZPseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling10.1038/s42003-021-02566-42399-3642https://doaj.org/article/ccf2e3e15e54451f801b309bb3ca68102021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02566-4https://doaj.org/toc/2399-3642Bock et al. characterise the adaptation of Pseudomonas aeruginosa to the antiseptic octenidine, using whole genome sequencing, gene expression studies and metabolomics. They attribute this increased tolerance to synergistic changes in efflux and plasma membrane composition via mutations in SmvR, the regulator of MFS efflux pump SmvA, and in phospholipid pathway proteins PssA and PgsA.Lucy J. BockPhilip M. FergusonMaria ClarkeVichayanee PumpitakkulMatthew E. WandPaul-Enguerrand FadyLeanne AllisonRoland A. FleckMatthew J. ShepherdA. James MasonJ. Mark SuttonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lucy J. Bock Philip M. Ferguson Maria Clarke Vichayanee Pumpitakkul Matthew E. Wand Paul-Enguerrand Fady Leanne Allison Roland A. Fleck Matthew J. Shepherd A. James Mason J. Mark Sutton Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
description	Bock et al. characterise the adaptation of Pseudomonas aeruginosa to the antiseptic octenidine, using whole genome sequencing, gene expression studies and metabolomics. They attribute this increased tolerance to synergistic changes in efflux and plasma membrane composition via mutations in SmvR, the regulator of MFS efflux pump SmvA, and in phospholipid pathway proteins PssA and PgsA.
format	article
author	Lucy J. Bock Philip M. Ferguson Maria Clarke Vichayanee Pumpitakkul Matthew E. Wand Paul-Enguerrand Fady Leanne Allison Roland A. Fleck Matthew J. Shepherd A. James Mason J. Mark Sutton
author_facet	Lucy J. Bock Philip M. Ferguson Maria Clarke Vichayanee Pumpitakkul Matthew E. Wand Paul-Enguerrand Fady Leanne Allison Roland A. Fleck Matthew J. Shepherd A. James Mason J. Mark Sutton
author_sort	Lucy J. Bock
title	Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
title_short	Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
title_full	Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
title_fullStr	Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
title_full_unstemmed	Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
title_sort	pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ccf2e3e15e54451f801b309bb3ca6810
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Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling

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