The transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles

Rewriting genomes allows for complete annotation of gene regulatory elements. Here the authors compare endogenous and rewritten segments of a genome and find extensive transcriptional changes, based on which they formulate design principles that aid in the programming of biological systems.

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Autores principales:	Mariëlle J. F. M. van Kooten, Clio A. Scheidegger, Matthias Christen, Beat Christen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccf4854386d044bab964b2abe2e588e7
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spelling	oai:doaj.org-article:ccf4854386d044bab964b2abe2e588e72021-12-02T14:42:18ZThe transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles10.1038/s41467-021-23362-y2041-1723https://doaj.org/article/ccf4854386d044bab964b2abe2e588e72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23362-yhttps://doaj.org/toc/2041-1723Rewriting genomes allows for complete annotation of gene regulatory elements. Here the authors compare endogenous and rewritten segments of a genome and find extensive transcriptional changes, based on which they formulate design principles that aid in the programming of biological systems.Mariëlle J. F. M. van KootenClio A. ScheideggerMatthias ChristenBeat ChristenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariëlle J. F. M. van Kooten Clio A. Scheidegger Matthias Christen Beat Christen The transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles
description	Rewriting genomes allows for complete annotation of gene regulatory elements. Here the authors compare endogenous and rewritten segments of a genome and find extensive transcriptional changes, based on which they formulate design principles that aid in the programming of biological systems.
format	article
author	Mariëlle J. F. M. van Kooten Clio A. Scheidegger Matthias Christen Beat Christen
author_facet	Mariëlle J. F. M. van Kooten Clio A. Scheidegger Matthias Christen Beat Christen
author_sort	Mariëlle J. F. M. van Kooten
title	The transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles
title_short	The transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles
title_full	The transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles
title_fullStr	The transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles
title_full_unstemmed	The transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles
title_sort	transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ccf4854386d044bab964b2abe2e588e7
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The transcriptional landscape of a rewritten bacterial genome reveals control elements and genome design principles

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