Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus

Bed nets treated with insecticides have been instrumental in reducing malaria mortality, but insecticide resistance is on the rise. Here, Mugenzi et al. identify genetic variants in the P450 gene CYP6P9b of Anopheles funestus that associate with insecticide resistance and develop a PCR-based diagnos...

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Autores principales:	Leon M. J. Mugenzi, Benjamin D. Menze, Magellan Tchouakui, Murielle J. Wondji, Helen Irving, Micareme Tchoupo, Jack Hearn, Gareth D. Weedall, Jacob M. Riveron, Charles S. Wondji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccf4a881a06c4c60933c5e58ed594e6b
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spelling	oai:doaj.org-article:ccf4a881a06c4c60933c5e58ed594e6b2021-12-02T15:35:06ZCis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus10.1038/s41467-019-12686-52041-1723https://doaj.org/article/ccf4a881a06c4c60933c5e58ed594e6b2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12686-5https://doaj.org/toc/2041-1723Bed nets treated with insecticides have been instrumental in reducing malaria mortality, but insecticide resistance is on the rise. Here, Mugenzi et al. identify genetic variants in the P450 gene CYP6P9b of Anopheles funestus that associate with insecticide resistance and develop a PCR-based diagnostic assay to help identify pyrethroid-resistant strains.Leon M. J. MugenziBenjamin D. MenzeMagellan TchouakuiMurielle J. WondjiHelen IrvingMicareme TchoupoJack HearnGareth D. WeedallJacob M. RiveronCharles S. WondjiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leon M. J. Mugenzi Benjamin D. Menze Magellan Tchouakui Murielle J. Wondji Helen Irving Micareme Tchoupo Jack Hearn Gareth D. Weedall Jacob M. Riveron Charles S. Wondji Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus
description	Bed nets treated with insecticides have been instrumental in reducing malaria mortality, but insecticide resistance is on the rise. Here, Mugenzi et al. identify genetic variants in the P450 gene CYP6P9b of Anopheles funestus that associate with insecticide resistance and develop a PCR-based diagnostic assay to help identify pyrethroid-resistant strains.
format	article
author	Leon M. J. Mugenzi Benjamin D. Menze Magellan Tchouakui Murielle J. Wondji Helen Irving Micareme Tchoupo Jack Hearn Gareth D. Weedall Jacob M. Riveron Charles S. Wondji
author_facet	Leon M. J. Mugenzi Benjamin D. Menze Magellan Tchouakui Murielle J. Wondji Helen Irving Micareme Tchoupo Jack Hearn Gareth D. Weedall Jacob M. Riveron Charles S. Wondji
author_sort	Leon M. J. Mugenzi
title	Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus
title_short	Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus
title_full	Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus
title_fullStr	Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus
title_full_unstemmed	Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus
title_sort	cis-regulatory cyp6p9b p450 variants associated with loss of insecticide-treated bed net efficacy against anopheles funestus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ccf4a881a06c4c60933c5e58ed594e6b
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Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus

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