Effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats

Florfenicol (FLO) is a third-generation veterinary antibiotic with a high residue detection rate in food, which cause the toxicity of FLO even at low doses, receiving notable attention. The impact of FLO exposure during early life on health and gut microbiota is still unclear. Here, the effects of F...

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Autores principales:	Zheng Ma, Lin Lin, Xiao Yang, Ya Yuan, Xiaoyan Fu, Shijia Chen, Wenbo Hu, Jinyao Chen, Hang Xiao, Xiangyi Wei, Juan Dai
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Toxicity Florfenicol Early-life Gut microbiota Drug resistance genes Metabolome Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/ccf5baa4f1c44cb9ae3917080123c534
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spelling	oai:doaj.org-article:ccf5baa4f1c44cb9ae3917080123c5342021-12-04T04:32:02ZEffects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats0147-651310.1016/j.ecoenv.2021.113038https://doaj.org/article/ccf5baa4f1c44cb9ae3917080123c5342021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321011507https://doaj.org/toc/0147-6513Florfenicol (FLO) is a third-generation veterinary antibiotic with a high residue detection rate in food, which cause the toxicity of FLO even at low doses, receiving notable attention. The impact of FLO exposure during early life on health and gut microbiota is still unclear. Here, the effects of FLO exposure on toxicity, gut microbiota, drug resistance genes, and the fecal metabolome during early life were investigated in suckling Sprague-Dawley (SD) rats. The results showed that FLO exposure during early life significantly increased the body weight, and WBC and LY levels in the blood, induced inflammation in the liver and intestines. FLO had a dose-dependent effect on the alpha and beta diversity of the gut microbiota, increasing the ratio of Firmicutes to Bacteroides and the abundance of some pathogenic bacteria, and changing the abundance of bacteria related to energy metabolism and inflammation, also promoted the enrichment of drug resistance genes. The fecal metabolome also demonstrated the effect of FLO exposure on metabolic pathways related to energy metabolism and inflammation. In conclusion, this research shows that FLO exposure during early life can lead to excessive weight gain, an inflammatory response, gut microbiota imbalance, the enrichment of drug resistance genes, and effects on related metabolic pathways.Zheng MaLin LinXiao YangYa YuanXiaoyan FuShijia ChenWenbo HuJinyao ChenHang XiaoXiangyi WeiJuan DaiElsevierarticleToxicityFlorfenicolEarly-lifeGut microbiotaDrug resistance genesMetabolomeEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 113038- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Toxicity Florfenicol Early-life Gut microbiota Drug resistance genes Metabolome Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Toxicity Florfenicol Early-life Gut microbiota Drug resistance genes Metabolome Environmental pollution TD172-193.5 Environmental sciences GE1-350 Zheng Ma Lin Lin Xiao Yang Ya Yuan Xiaoyan Fu Shijia Chen Wenbo Hu Jinyao Chen Hang Xiao Xiangyi Wei Juan Dai Effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats
description	Florfenicol (FLO) is a third-generation veterinary antibiotic with a high residue detection rate in food, which cause the toxicity of FLO even at low doses, receiving notable attention. The impact of FLO exposure during early life on health and gut microbiota is still unclear. Here, the effects of FLO exposure on toxicity, gut microbiota, drug resistance genes, and the fecal metabolome during early life were investigated in suckling Sprague-Dawley (SD) rats. The results showed that FLO exposure during early life significantly increased the body weight, and WBC and LY levels in the blood, induced inflammation in the liver and intestines. FLO had a dose-dependent effect on the alpha and beta diversity of the gut microbiota, increasing the ratio of Firmicutes to Bacteroides and the abundance of some pathogenic bacteria, and changing the abundance of bacteria related to energy metabolism and inflammation, also promoted the enrichment of drug resistance genes. The fecal metabolome also demonstrated the effect of FLO exposure on metabolic pathways related to energy metabolism and inflammation. In conclusion, this research shows that FLO exposure during early life can lead to excessive weight gain, an inflammatory response, gut microbiota imbalance, the enrichment of drug resistance genes, and effects on related metabolic pathways.
format	article
author	Zheng Ma Lin Lin Xiao Yang Ya Yuan Xiaoyan Fu Shijia Chen Wenbo Hu Jinyao Chen Hang Xiao Xiangyi Wei Juan Dai
author_facet	Zheng Ma Lin Lin Xiao Yang Ya Yuan Xiaoyan Fu Shijia Chen Wenbo Hu Jinyao Chen Hang Xiao Xiangyi Wei Juan Dai
author_sort	Zheng Ma
title	Effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats
title_short	Effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats
title_full	Effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats
title_fullStr	Effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats
title_full_unstemmed	Effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats
title_sort	effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in sd rats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ccf5baa4f1c44cb9ae3917080123c534
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Effects of florfenicol exposure during early life on toxicity, gut microbiota, and fecal metabolome in SD rats

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