The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment

Metabolic reprogramming is a well-known hallmark of cancer, whereby the development of drugs that target cancer cell metabolism is gaining momentum. However, when establishing preclinical studies and clinical trials, it is often neglected that a tumor mass is a complex system in which cancer cells c...

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Autores principales:	Maria Iorio, Nikkitha Umesh Ganesh, Monica De Luise, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer metabolism tumor microenvironment metabolic reprogramming cancer-associated fibroblasts tumor-associated macrophages Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ccf5fe5ac1414c61949601ee862d928c
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spelling	oai:doaj.org-article:ccf5fe5ac1414c61949601ee862d928c2021-11-11T15:32:58ZThe Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment10.3390/cancers132154472072-6694https://doaj.org/article/ccf5fe5ac1414c61949601ee862d928c2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5447https://doaj.org/toc/2072-6694Metabolic reprogramming is a well-known hallmark of cancer, whereby the development of drugs that target cancer cell metabolism is gaining momentum. However, when establishing preclinical studies and clinical trials, it is often neglected that a tumor mass is a complex system in which cancer cells coexist and interact with several types of microenvironment populations, including endothelial cells, fibroblasts and immune cells. We are just starting to understand how such populations are affected by the metabolic changes occurring in a transformed cell and little is known about the impact of metabolism-targeting drugs on the non-malignant tumor components. Here we provide a general overview of the links between cancer cell metabolism and tumor microenvironment (TME), particularly focusing on the emerging literature reporting TME-specific effects of metabolic therapies.Maria IorioNikkitha Umesh GaneshMonica De LuiseAnna Maria PorcelliGiuseppe GasparreIvana KurelacMDPI AGarticlecancer metabolismtumor microenvironmentmetabolic reprogrammingcancer-associated fibroblaststumor-associated macrophagesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5447, p 5447 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer metabolism tumor microenvironment metabolic reprogramming cancer-associated fibroblasts tumor-associated macrophages Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancer metabolism tumor microenvironment metabolic reprogramming cancer-associated fibroblasts tumor-associated macrophages Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Maria Iorio Nikkitha Umesh Ganesh Monica De Luise Anna Maria Porcelli Giuseppe Gasparre Ivana Kurelac The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment
description	Metabolic reprogramming is a well-known hallmark of cancer, whereby the development of drugs that target cancer cell metabolism is gaining momentum. However, when establishing preclinical studies and clinical trials, it is often neglected that a tumor mass is a complex system in which cancer cells coexist and interact with several types of microenvironment populations, including endothelial cells, fibroblasts and immune cells. We are just starting to understand how such populations are affected by the metabolic changes occurring in a transformed cell and little is known about the impact of metabolism-targeting drugs on the non-malignant tumor components. Here we provide a general overview of the links between cancer cell metabolism and tumor microenvironment (TME), particularly focusing on the emerging literature reporting TME-specific effects of metabolic therapies.
format	article
author	Maria Iorio Nikkitha Umesh Ganesh Monica De Luise Anna Maria Porcelli Giuseppe Gasparre Ivana Kurelac
author_facet	Maria Iorio Nikkitha Umesh Ganesh Monica De Luise Anna Maria Porcelli Giuseppe Gasparre Ivana Kurelac
author_sort	Maria Iorio
title	The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment
title_short	The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment
title_full	The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment
title_fullStr	The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment
title_full_unstemmed	The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment
title_sort	neglected liaison: targeting cancer cell metabolic reprogramming modifies the composition of non-malignant populations of the tumor microenvironment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ccf5fe5ac1414c61949601ee862d928c
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The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment

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