Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses

Mayaro virus (MAYV) is an emerging arbovirus in Central and South America that is transmitted by mosquitoes and causes arthritogenic disease. Here, the authors present the 4.4 Å resolution cryo-EM structure of MAYV and describe specific features of the virus, which could be exploited for the design...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Helder V. Ribeiro-Filho, Lais D. Coimbra, Alexandre Cassago, Rebeca P. F. Rocha, João Victor da Silva Guerra, Rafael de Felicio, Carolina Moretto Carnieli, Luiza Leme, Antonio Cláudio Padilha, Adriana F. Paes Leme, Daniela B. B. Trivella, Rodrigo Villares Portugal, Paulo Sérgio Lopes-de-Oliveira, Rafael Elias Marques
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccf9e12fb93247bf974fca9104dc9dea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ccf9e12fb93247bf974fca9104dc9dea
record_format	dspace
spelling	oai:doaj.org-article:ccf9e12fb93247bf974fca9104dc9dea2021-12-02T16:52:57ZCryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses10.1038/s41467-021-23400-92041-1723https://doaj.org/article/ccf9e12fb93247bf974fca9104dc9dea2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23400-9https://doaj.org/toc/2041-1723Mayaro virus (MAYV) is an emerging arbovirus in Central and South America that is transmitted by mosquitoes and causes arthritogenic disease. Here, the authors present the 4.4 Å resolution cryo-EM structure of MAYV and describe specific features of the virus, which could be exploited for the design of MAYV-specific diagnostics and therapeutics.Helder V. Ribeiro-FilhoLais D. CoimbraAlexandre CassagoRebeca P. F. RochaJoão Victor da Silva GuerraRafael de FelicioCarolina Moretto CarnieliLuiza LemeAntonio Cláudio PadilhaAdriana F. Paes LemeDaniela B. B. TrivellaRodrigo Villares PortugalPaulo Sérgio Lopes-de-OliveiraRafael Elias MarquesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Helder V. Ribeiro-Filho Lais D. Coimbra Alexandre Cassago Rebeca P. F. Rocha João Victor da Silva Guerra Rafael de Felicio Carolina Moretto Carnieli Luiza Leme Antonio Cláudio Padilha Adriana F. Paes Leme Daniela B. B. Trivella Rodrigo Villares Portugal Paulo Sérgio Lopes-de-Oliveira Rafael Elias Marques Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses
description	Mayaro virus (MAYV) is an emerging arbovirus in Central and South America that is transmitted by mosquitoes and causes arthritogenic disease. Here, the authors present the 4.4 Å resolution cryo-EM structure of MAYV and describe specific features of the virus, which could be exploited for the design of MAYV-specific diagnostics and therapeutics.
format	article
author	Helder V. Ribeiro-Filho Lais D. Coimbra Alexandre Cassago Rebeca P. F. Rocha João Victor da Silva Guerra Rafael de Felicio Carolina Moretto Carnieli Luiza Leme Antonio Cláudio Padilha Adriana F. Paes Leme Daniela B. B. Trivella Rodrigo Villares Portugal Paulo Sérgio Lopes-de-Oliveira Rafael Elias Marques
author_facet	Helder V. Ribeiro-Filho Lais D. Coimbra Alexandre Cassago Rebeca P. F. Rocha João Victor da Silva Guerra Rafael de Felicio Carolina Moretto Carnieli Luiza Leme Antonio Cláudio Padilha Adriana F. Paes Leme Daniela B. B. Trivella Rodrigo Villares Portugal Paulo Sérgio Lopes-de-Oliveira Rafael Elias Marques
author_sort	Helder V. Ribeiro-Filho
title	Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses
title_short	Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses
title_full	Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses
title_fullStr	Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses
title_full_unstemmed	Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses
title_sort	cryo-em structure of the mature and infective mayaro virus at 4.4 å resolution reveals features of arthritogenic alphaviruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ccf9e12fb93247bf974fca9104dc9dea
work_keys_str_mv	AT heldervribeirofilho cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT laisdcoimbra cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT alexandrecassago cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT rebecapfrocha cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT joaovictordasilvaguerra cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT rafaeldefelicio cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT carolinamorettocarnieli cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT luizaleme cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT antonioclaudiopadilha cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT adrianafpaesleme cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT danielabbtrivella cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT rodrigovillaresportugal cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT paulosergiolopesdeoliveira cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses AT rafaeleliasmarques cryoemstructureofthematureandinfectivemayarovirusat44aresolutionrevealsfeaturesofarthritogenicalphaviruses
_version_	1718382945409957888

Cryo-EM structure of the mature and infective Mayaro virus at 4.4 Å resolution reveals features of arthritogenic alphaviruses

Ejemplares similares