Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer

Colorectal cancer (CRC) involving a malignant tumour remains one of the greatest contributing causes of fatal mortality and has become the third globally ranked malignancy in terms of cancer-associated deaths. Conventional CRC treatment approaches such as surgery, radiation, and chemotherapy are the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nokuphila Winifred Nompumelelo Simelane, Heidi Abrahamse
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colorectal cancer photodynamic therapy photosensitizers nanotechnology 3D models Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ccfb027c327a40d6a80f3c9eac747a45
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ccfb027c327a40d6a80f3c9eac747a45
record_format	dspace
spelling	oai:doaj.org-article:ccfb027c327a40d6a80f3c9eac747a452021-11-25T17:56:21ZNanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer10.3390/ijms2222124051422-00671661-6596https://doaj.org/article/ccfb027c327a40d6a80f3c9eac747a452021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12405https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Colorectal cancer (CRC) involving a malignant tumour remains one of the greatest contributing causes of fatal mortality and has become the third globally ranked malignancy in terms of cancer-associated deaths. Conventional CRC treatment approaches such as surgery, radiation, and chemotherapy are the most utilized approaches to treat this disease. However, they are limited by low selectivity and systemic toxicity, so they cannot completely eradicate this disease. Photodynamic therapy (PDT) is an emerging therapeutic modality that exerts selective cytotoxicity to cancerous cells through the activation of photosensitizers (PSs) under light irradiation to produce cytotoxic reactive oxygen species (ROS), which then cause cancer cell death. Cumulative research findings have highlighted the significant role of traditional PDT in CRC treatment; however, the therapeutic efficacy of the classical PDT strategy is restricted due to skin photosensitivity, poor cancerous tissue specificity, and limited penetration of light. The application of nanoparticles in PDT can mitigate some of these shortcomings and enhance the targeting ability of PS in order to effectively use PDT against CRC as well as to reduce systemic side effects. Although 2D culture models are widely used in cancer research, they have some limitations. Therefore, 3D models in CRC PDT, particularly multicellular tumour spheroids (MCTS), have attracted researchers. This review summarizes several photosensitizers that are currently used in CRC PDT and gives an overview of recent advances in nanoparticle application for enhanced CRC PDT. In addition, the progress of 3D-model applications in CRC PDT is discussed.Nokuphila Winifred Nompumelelo SimelaneHeidi AbrahamseMDPI AGarticlecolorectal cancerphotodynamic therapyphotosensitizersnanotechnology3D modelsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12405, p 12405 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer photodynamic therapy photosensitizers nanotechnology 3D models Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	colorectal cancer photodynamic therapy photosensitizers nanotechnology 3D models Biology (General) QH301-705.5 Chemistry QD1-999 Nokuphila Winifred Nompumelelo Simelane Heidi Abrahamse Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer
description	Colorectal cancer (CRC) involving a malignant tumour remains one of the greatest contributing causes of fatal mortality and has become the third globally ranked malignancy in terms of cancer-associated deaths. Conventional CRC treatment approaches such as surgery, radiation, and chemotherapy are the most utilized approaches to treat this disease. However, they are limited by low selectivity and systemic toxicity, so they cannot completely eradicate this disease. Photodynamic therapy (PDT) is an emerging therapeutic modality that exerts selective cytotoxicity to cancerous cells through the activation of photosensitizers (PSs) under light irradiation to produce cytotoxic reactive oxygen species (ROS), which then cause cancer cell death. Cumulative research findings have highlighted the significant role of traditional PDT in CRC treatment; however, the therapeutic efficacy of the classical PDT strategy is restricted due to skin photosensitivity, poor cancerous tissue specificity, and limited penetration of light. The application of nanoparticles in PDT can mitigate some of these shortcomings and enhance the targeting ability of PS in order to effectively use PDT against CRC as well as to reduce systemic side effects. Although 2D culture models are widely used in cancer research, they have some limitations. Therefore, 3D models in CRC PDT, particularly multicellular tumour spheroids (MCTS), have attracted researchers. This review summarizes several photosensitizers that are currently used in CRC PDT and gives an overview of recent advances in nanoparticle application for enhanced CRC PDT. In addition, the progress of 3D-model applications in CRC PDT is discussed.
format	article
author	Nokuphila Winifred Nompumelelo Simelane Heidi Abrahamse
author_facet	Nokuphila Winifred Nompumelelo Simelane Heidi Abrahamse
author_sort	Nokuphila Winifred Nompumelelo Simelane
title	Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer
title_short	Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer
title_full	Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer
title_fullStr	Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer
title_full_unstemmed	Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer
title_sort	nanoparticle-mediated delivery systems in photodynamic therapy of colorectal cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ccfb027c327a40d6a80f3c9eac747a45
work_keys_str_mv	AT nokuphilawinifrednompumelelosimelane nanoparticlemediateddeliverysystemsinphotodynamictherapyofcolorectalcancer AT heidiabrahamse nanoparticlemediateddeliverysystemsinphotodynamictherapyofcolorectalcancer
_version_	1718411830497378304

Nanoparticle-Mediated Delivery Systems in Photodynamic Therapy of Colorectal Cancer

Ejemplares similares