COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France

Abstract The variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (Southeast of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this area. A high incidence rate together with a fast turn-over of the main circulating va...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Johan Courjon, Julie Contenti, Elisa Demonchy, Jacques Levraut, Pascal Barbry, Géraldine Rios, Jean Dellamonica, David Chirio, Caroline Bonnefoy, Valérie Giordanengo, Michel Carles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ccfe3dbe8a484c0c8c3800949a624648
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ccfe3dbe8a484c0c8c3800949a624648
record_format	dspace
spelling	oai:doaj.org-article:ccfe3dbe8a484c0c8c3800949a6246482021-12-02T15:31:27ZCOVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France10.1038/s41598-021-95067-72045-2322https://doaj.org/article/ccfe3dbe8a484c0c8c3800949a6246482021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95067-7https://doaj.org/toc/2045-2322Abstract The variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (Southeast of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this area. A high incidence rate together with a fast turn-over of the main circulating variants, provided us the opportunity to analyze modifications in clinical profile and outcome traits. We performed an observational study in the University hospital of Nice from December 2020 to February 2021. We analyzed data of sequencing of SARS-CoV-2 from the sewage collector and PCR screening from all positive samples at the hospital. Then, we described the characteristics of all COVID-19 patients admitted in the emergency department (ED) (n = 1247) and those hospitalized in the infectious diseases ward or ICU (n = 232). The UK-variant was absent in this area in December, then increasingly spread in January representing 59% of the PCR screening performed mid-February. The rate of patients over 65 years admitted to the ED decreased from 63 to 50% (p = 0.001). The mean age of hospitalized patients in the infectious diseases ward decreased from 70.7 to 59.2 (p < 0.001) while the proportion of patients without comorbidity increased from 16 to 42% (p = 0.007). Spread of the UK-variant in the Southeast of France affects younger and healthier patients.Johan CourjonJulie ContentiElisa DemonchyJacques LevrautPascal BarbryGéraldine RiosJean DellamonicaDavid ChirioCaroline BonnefoyValérie GiordanengoMichel CarlesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johan Courjon Julie Contenti Elisa Demonchy Jacques Levraut Pascal Barbry Géraldine Rios Jean Dellamonica David Chirio Caroline Bonnefoy Valérie Giordanengo Michel Carles COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France
description	Abstract The variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (Southeast of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this area. A high incidence rate together with a fast turn-over of the main circulating variants, provided us the opportunity to analyze modifications in clinical profile and outcome traits. We performed an observational study in the University hospital of Nice from December 2020 to February 2021. We analyzed data of sequencing of SARS-CoV-2 from the sewage collector and PCR screening from all positive samples at the hospital. Then, we described the characteristics of all COVID-19 patients admitted in the emergency department (ED) (n = 1247) and those hospitalized in the infectious diseases ward or ICU (n = 232). The UK-variant was absent in this area in December, then increasingly spread in January representing 59% of the PCR screening performed mid-February. The rate of patients over 65 years admitted to the ED decreased from 63 to 50% (p = 0.001). The mean age of hospitalized patients in the infectious diseases ward decreased from 70.7 to 59.2 (p < 0.001) while the proportion of patients without comorbidity increased from 16 to 42% (p = 0.007). Spread of the UK-variant in the Southeast of France affects younger and healthier patients.
format	article
author	Johan Courjon Julie Contenti Elisa Demonchy Jacques Levraut Pascal Barbry Géraldine Rios Jean Dellamonica David Chirio Caroline Bonnefoy Valérie Giordanengo Michel Carles
author_facet	Johan Courjon Julie Contenti Elisa Demonchy Jacques Levraut Pascal Barbry Géraldine Rios Jean Dellamonica David Chirio Caroline Bonnefoy Valérie Giordanengo Michel Carles
author_sort	Johan Courjon
title	COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France
title_short	COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France
title_full	COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France
title_fullStr	COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France
title_full_unstemmed	COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France
title_sort	covid-19 patients age, comorbidity profiles and clinical presentation related to the sars-cov-2 uk-variant spread in the southeast of france
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ccfe3dbe8a484c0c8c3800949a624648
work_keys_str_mv	AT johancourjon covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT juliecontenti covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT elisademonchy covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT jacqueslevraut covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT pascalbarbry covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT geraldinerios covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT jeandellamonica covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT davidchirio covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT carolinebonnefoy covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT valeriegiordanengo covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance AT michelcarles covid19patientsagecomorbidityprofilesandclinicalpresentationrelatedtothesarscov2ukvariantspreadinthesoutheastoffrance
_version_	1718387170460303360

COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France

Ejemplares similares