The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales

Abstract Selenium (Se) is an essential human micronutrient. Deficiency of Se decreases the activity of selenoproteins and can compromise immune and thyroid function and cognitive development, and increase risks from non-communicable diseases. The prevalence of Se deficiency is unknown in many countr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Felix P. Phiri, E. Louise Ander, Elizabeth H. Bailey, Benson Chilima, Allan D. C. Chilimba, Jellita Gondwe, Edward J. M. Joy, Alexander A. Kalimbira, Diriba B. Kumssa, R. Murray Lark, John C. Phuka, Andrew Salter, Parminder S. Suchdev, Michael J. Watts, Scott D. Young, Martin R. Broadley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ccfebc51ff624e77b58b4c0b9028c7e4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ccfebc51ff624e77b58b4c0b9028c7e4
record_format	dspace
spelling	oai:doaj.org-article:ccfebc51ff624e77b58b4c0b9028c7e42021-12-02T15:09:40ZThe risk of selenium deficiency in Malawi is large and varies over multiple spatial scales10.1038/s41598-019-43013-z2045-2322https://doaj.org/article/ccfebc51ff624e77b58b4c0b9028c7e42019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-43013-zhttps://doaj.org/toc/2045-2322Abstract Selenium (Se) is an essential human micronutrient. Deficiency of Se decreases the activity of selenoproteins and can compromise immune and thyroid function and cognitive development, and increase risks from non-communicable diseases. The prevalence of Se deficiency is unknown in many countries, especially in sub-Saharan Africa (SSA). Here we report that the risk of Se deficiency in Malawi is large among a nationally representative population of 2,761 people. For example, 62.5% and 29.6% of women of reproductive age (WRA, n = 802) had plasma Se concentrations below the thresholds for the optimal activity of the selenoproteins glutathione peroxidase 3 (GPx3; <86.9 ng mL−1) and iodothyronine deiodinase (IDI; <64.8 ng mL−1), respectively. This is the first nationally representative evidence of widespread Se deficiency in SSA. Geostatistical modelling shows that Se deficiency risks are influenced by soil type, and also by proximity to Lake Malawi where more fish is likely to be consumed. Selenium deficiency should be quantified more widely in existing national micronutrient surveillance programmes in SSA given the marginal additional cost this would incur.Felix P. PhiriE. Louise AnderElizabeth H. BaileyBenson ChilimaAllan D. C. ChilimbaJellita GondweEdward J. M. JoyAlexander A. KalimbiraDiriba B. KumssaR. Murray LarkJohn C. PhukaAndrew SalterParminder S. SuchdevMichael J. WattsScott D. YoungMartin R. BroadleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Felix P. Phiri E. Louise Ander Elizabeth H. Bailey Benson Chilima Allan D. C. Chilimba Jellita Gondwe Edward J. M. Joy Alexander A. Kalimbira Diriba B. Kumssa R. Murray Lark John C. Phuka Andrew Salter Parminder S. Suchdev Michael J. Watts Scott D. Young Martin R. Broadley The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales
description	Abstract Selenium (Se) is an essential human micronutrient. Deficiency of Se decreases the activity of selenoproteins and can compromise immune and thyroid function and cognitive development, and increase risks from non-communicable diseases. The prevalence of Se deficiency is unknown in many countries, especially in sub-Saharan Africa (SSA). Here we report that the risk of Se deficiency in Malawi is large among a nationally representative population of 2,761 people. For example, 62.5% and 29.6% of women of reproductive age (WRA, n = 802) had plasma Se concentrations below the thresholds for the optimal activity of the selenoproteins glutathione peroxidase 3 (GPx3; <86.9 ng mL−1) and iodothyronine deiodinase (IDI; <64.8 ng mL−1), respectively. This is the first nationally representative evidence of widespread Se deficiency in SSA. Geostatistical modelling shows that Se deficiency risks are influenced by soil type, and also by proximity to Lake Malawi where more fish is likely to be consumed. Selenium deficiency should be quantified more widely in existing national micronutrient surveillance programmes in SSA given the marginal additional cost this would incur.
format	article
author	Felix P. Phiri E. Louise Ander Elizabeth H. Bailey Benson Chilima Allan D. C. Chilimba Jellita Gondwe Edward J. M. Joy Alexander A. Kalimbira Diriba B. Kumssa R. Murray Lark John C. Phuka Andrew Salter Parminder S. Suchdev Michael J. Watts Scott D. Young Martin R. Broadley
author_facet	Felix P. Phiri E. Louise Ander Elizabeth H. Bailey Benson Chilima Allan D. C. Chilimba Jellita Gondwe Edward J. M. Joy Alexander A. Kalimbira Diriba B. Kumssa R. Murray Lark John C. Phuka Andrew Salter Parminder S. Suchdev Michael J. Watts Scott D. Young Martin R. Broadley
author_sort	Felix P. Phiri
title	The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales
title_short	The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales
title_full	The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales
title_fullStr	The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales
title_full_unstemmed	The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales
title_sort	risk of selenium deficiency in malawi is large and varies over multiple spatial scales
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ccfebc51ff624e77b58b4c0b9028c7e4
work_keys_str_mv	AT felixpphiri theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT elouiseander theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT elizabethhbailey theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT bensonchilima theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT allandcchilimba theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT jellitagondwe theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT edwardjmjoy theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT alexanderakalimbira theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT diribabkumssa theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT rmurraylark theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT johncphuka theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT andrewsalter theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT parminderssuchdev theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT michaeljwatts theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT scottdyoung theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT martinrbroadley theriskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT felixpphiri riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT elouiseander riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT elizabethhbailey riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT bensonchilima riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT allandcchilimba riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT jellitagondwe riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT edwardjmjoy riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT alexanderakalimbira riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT diribabkumssa riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT rmurraylark riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT johncphuka riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT andrewsalter riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT parminderssuchdev riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT michaeljwatts riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT scottdyoung riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales AT martinrbroadley riskofseleniumdeficiencyinmalawiislargeandvariesovermultiplespatialscales
_version_	1718387779684007936

The risk of selenium deficiency in Malawi is large and varies over multiple spatial scales

Ejemplares similares