Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

Liver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic fluxes by using lactate and glucose tracers in combina...

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Autores principales:	Rachel J. Perry, Liang Peng, Gary W. Cline, Gina M. Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L. Rothman, Kitt Falk Petersen, Gerald I. Shulman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ccfedb92246c4972a9596277dbe5a31b
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spelling	oai:doaj.org-article:ccfedb92246c4972a9596277dbe5a31b2021-12-02T17:06:00ZNon-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)10.1038/s41467-017-01143-w2041-1723https://doaj.org/article/ccfedb92246c4972a9596277dbe5a31b2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01143-whttps://doaj.org/toc/2041-1723Liver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic fluxes by using lactate and glucose tracers in combination with NMR spectroscopy.Rachel J. PerryLiang PengGary W. ClineGina M. ButricoYongliang WangXian-Man ZhangDouglas L. RothmanKitt Falk PetersenGerald I. ShulmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rachel J. Perry Liang Peng Gary W. Cline Gina M. Butrico Yongliang Wang Xian-Man Zhang Douglas L. Rothman Kitt Falk Petersen Gerald I. Shulman Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
description	Liver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic fluxes by using lactate and glucose tracers in combination with NMR spectroscopy.
format	article
author	Rachel J. Perry Liang Peng Gary W. Cline Gina M. Butrico Yongliang Wang Xian-Man Zhang Douglas L. Rothman Kitt Falk Petersen Gerald I. Shulman
author_facet	Rachel J. Perry Liang Peng Gary W. Cline Gina M. Butrico Yongliang Wang Xian-Man Zhang Douglas L. Rothman Kitt Falk Petersen Gerald I. Shulman
author_sort	Rachel J. Perry
title	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_short	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_full	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_fullStr	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_full_unstemmed	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_sort	non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer nmr tracer analysis (pinta)
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ccfedb92246c4972a9596277dbe5a31b
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Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

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