Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients
Here, the authors characterize immunological and microbiome alterations in a cohort of obese asthmatics, finding that disease severity negatively correlates with fecal abundance of Akkermansia muciniphila, and show in a mouse model that administration of A. muciniphila reduces airway hyper-reactivit...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/cd01b505faaf4615b453f12d29b2725d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:cd01b505faaf4615b453f12d29b2725d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:cd01b505faaf4615b453f12d29b2725d2021-12-02T15:35:12ZObesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients10.1038/s41467-019-13751-92041-1723https://doaj.org/article/cd01b505faaf4615b453f12d29b2725d2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13751-9https://doaj.org/toc/2041-1723Here, the authors characterize immunological and microbiome alterations in a cohort of obese asthmatics, finding that disease severity negatively correlates with fecal abundance of Akkermansia muciniphila, and show in a mouse model that administration of A. muciniphila reduces airway hyper-reactivity and airway inflammation.David MichalovichNoelia Rodriguez-PerezSylwia SmolinskaMichal PirozynskiDavid MayhewSorif UddinStephanie Van HornMilena SokolowskaCan AltunbulakliAndrzej EljaszewiczBenoit PuginWeronika BarcikMagdalena Kurnik-LuckaKen A. SaundersKaren D. SimpsonPeter Schmid-GrendelmeierRuth FerstlRemo FreiNoriane SieviMalcolm KohlerPawel GajdanowiczKatrine B. GraversenKatrine Lindholm BøghMarek JutelJames R. BrownCezmi A. AkdisEdith M. HesselLiam O’MahonyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David Michalovich Noelia Rodriguez-Perez Sylwia Smolinska Michal Pirozynski David Mayhew Sorif Uddin Stephanie Van Horn Milena Sokolowska Can Altunbulakli Andrzej Eljaszewicz Benoit Pugin Weronika Barcik Magdalena Kurnik-Lucka Ken A. Saunders Karen D. Simpson Peter Schmid-Grendelmeier Ruth Ferstl Remo Frei Noriane Sievi Malcolm Kohler Pawel Gajdanowicz Katrine B. Graversen Katrine Lindholm Bøgh Marek Jutel James R. Brown Cezmi A. Akdis Edith M. Hessel Liam O’Mahony Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients |
| description |
Here, the authors characterize immunological and microbiome alterations in a cohort of obese asthmatics, finding that disease severity negatively correlates with fecal abundance of Akkermansia muciniphila, and show in a mouse model that administration of A. muciniphila reduces airway hyper-reactivity and airway inflammation. |
| format |
article |
| author |
David Michalovich Noelia Rodriguez-Perez Sylwia Smolinska Michal Pirozynski David Mayhew Sorif Uddin Stephanie Van Horn Milena Sokolowska Can Altunbulakli Andrzej Eljaszewicz Benoit Pugin Weronika Barcik Magdalena Kurnik-Lucka Ken A. Saunders Karen D. Simpson Peter Schmid-Grendelmeier Ruth Ferstl Remo Frei Noriane Sievi Malcolm Kohler Pawel Gajdanowicz Katrine B. Graversen Katrine Lindholm Bøgh Marek Jutel James R. Brown Cezmi A. Akdis Edith M. Hessel Liam O’Mahony |
| author_facet |
David Michalovich Noelia Rodriguez-Perez Sylwia Smolinska Michal Pirozynski David Mayhew Sorif Uddin Stephanie Van Horn Milena Sokolowska Can Altunbulakli Andrzej Eljaszewicz Benoit Pugin Weronika Barcik Magdalena Kurnik-Lucka Ken A. Saunders Karen D. Simpson Peter Schmid-Grendelmeier Ruth Ferstl Remo Frei Noriane Sievi Malcolm Kohler Pawel Gajdanowicz Katrine B. Graversen Katrine Lindholm Bøgh Marek Jutel James R. Brown Cezmi A. Akdis Edith M. Hessel Liam O’Mahony |
| author_sort |
David Michalovich |
| title |
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients |
| title_short |
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients |
| title_full |
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients |
| title_fullStr |
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients |
| title_full_unstemmed |
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients |
| title_sort |
obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/cd01b505faaf4615b453f12d29b2725d |
| work_keys_str_mv |
AT davidmichalovich obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT noeliarodriguezperez obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT sylwiasmolinska obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT michalpirozynski obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT davidmayhew obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT sorifuddin obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT stephanievanhorn obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT milenasokolowska obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT canaltunbulakli obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT andrzejeljaszewicz obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT benoitpugin obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT weronikabarcik obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT magdalenakurniklucka obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT kenasaunders obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT karendsimpson obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT peterschmidgrendelmeier obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT ruthferstl obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT remofrei obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT norianesievi obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT malcolmkohler obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT pawelgajdanowicz obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT katrinebgraversen obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT katrinelindholmbøgh obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT marekjutel obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT jamesrbrown obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT cezmiaakdis obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT edithmhessel obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients AT liamomahony obesityanddiseaseseveritymagnifydisturbedmicrobiomeimmuneinteractionsinasthmapatients |
| _version_ |
1718386624416448512 |