Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections

This review article analyzes the data on the role of selenium in the regulation of the metabolic and immune status of a macroorganism. The data on endogenousfunctional selenium-containing molecules, which include selenocysteine, selenomethionine, and selenoproteins, are considered. The data on the p...

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Autores principales:	O. V. Yurieva, V. I. Dubrovina, A. B. Pyatidesyatnikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	synthetic organoselenium compounds selenoprotein mimetics correction of metabolic and immune status Science Q
Acceso en línea:	https://doaj.org/article/cd02fa8ba03441138f9a88fc9ead5f87
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spelling	oai:doaj.org-article:cd02fa8ba03441138f9a88fc9ead5f872021-11-23T06:14:46ZProspects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections2541-94202587-959610.29413/ABS.2021-6.3.6https://doaj.org/article/cd02fa8ba03441138f9a88fc9ead5f872021-08-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2847https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596This review article analyzes the data on the role of selenium in the regulation of the metabolic and immune status of a macroorganism. The data on endogenousfunctional selenium-containing molecules, which include selenocysteine, selenomethionine, and selenoproteins, are considered. The data on the pathologies associated with the deficiency of this microelement, its immunotropic properties and adjuvant effects are presented. The role of selenoproteins in the regulation of redox processes has been shown. The data on the immunotropic activity of compounds containing selenium and the prospects for their use as adjuvants are analyzed. The last section is devoted to the analysis of literature data on the biological properties of synthetic selenium compounds with an activity that mimics the catalytic activity of selenoproteins. The analysis of the data on the functional activity of selenoproteins carried out in this work indicates their key role in the regulation of metabolic and immune processes, as well as in maintaining homeostasis. The information presented in this review on the biological activity and mechanisms of action of new synthetic low-toxic organic compounds of selenium can serve as a basis for the development of nonspecific means of metabolic and immune correction of vaccinal processes caused by both live attenuated vaccines and artificially created ones.O. V. YurievaV. I. DubrovinaA. B. PyatidesyatnikovaScientific Сentre for Family Health and Human Reproduction Problemsarticlesynthetic organoselenium compoundsselenoprotein mimeticscorrection of metabolic and immune statusScienceQRUActa Biomedica Scientifica, Vol 6, Iss 3, Pp 60-69 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	synthetic organoselenium compounds selenoprotein mimetics correction of metabolic and immune status Science Q
spellingShingle	synthetic organoselenium compounds selenoprotein mimetics correction of metabolic and immune status Science Q O. V. Yurieva V. I. Dubrovina A. B. Pyatidesyatnikova Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections
description	This review article analyzes the data on the role of selenium in the regulation of the metabolic and immune status of a macroorganism. The data on endogenousfunctional selenium-containing molecules, which include selenocysteine, selenomethionine, and selenoproteins, are considered. The data on the pathologies associated with the deficiency of this microelement, its immunotropic properties and adjuvant effects are presented. The role of selenoproteins in the regulation of redox processes has been shown. The data on the immunotropic activity of compounds containing selenium and the prospects for their use as adjuvants are analyzed. The last section is devoted to the analysis of literature data on the biological properties of synthetic selenium compounds with an activity that mimics the catalytic activity of selenoproteins. The analysis of the data on the functional activity of selenoproteins carried out in this work indicates their key role in the regulation of metabolic and immune processes, as well as in maintaining homeostasis. The information presented in this review on the biological activity and mechanisms of action of new synthetic low-toxic organic compounds of selenium can serve as a basis for the development of nonspecific means of metabolic and immune correction of vaccinal processes caused by both live attenuated vaccines and artificially created ones.
format	article
author	O. V. Yurieva V. I. Dubrovina A. B. Pyatidesyatnikova
author_facet	O. V. Yurieva V. I. Dubrovina A. B. Pyatidesyatnikova
author_sort	O. V. Yurieva
title	Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections
title_short	Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections
title_full	Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections
title_fullStr	Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections
title_full_unstemmed	Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections
title_sort	prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/cd02fa8ba03441138f9a88fc9ead5f87
work_keys_str_mv	AT ovyurieva prospectsfortheuseofsyntheticorganoseleniumcompoundsforthecorrectionofmetabolicandimmunestatusduringvaccinationwithliveattenuatedvaccinesagainstespeciallydangerousinfections AT vidubrovina prospectsfortheuseofsyntheticorganoseleniumcompoundsforthecorrectionofmetabolicandimmunestatusduringvaccinationwithliveattenuatedvaccinesagainstespeciallydangerousinfections AT abpyatidesyatnikova prospectsfortheuseofsyntheticorganoseleniumcompoundsforthecorrectionofmetabolicandimmunestatusduringvaccinationwithliveattenuatedvaccinesagainstespeciallydangerousinfections
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Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections

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